@article{3102585,
    title = "Richter's transformation as leptomeningeal infiltration in a chronic lymphocytic leukemia patient receiving venetoclax. Could blood-brain barrier be a disease “sanctuary” during venetoclax treatment?",
    author = "Dimou, M. and Bitsani, A. and Roumelioti, M. and Dimitrakopoulou, A. and Iliakis, T. and Pardalis, V. and Grafakos, I. and Kalyva, S. and Markopoulos, A. and Kyrtsonis, M.-C. and Panayiotidis, P.",
    journal = "Clinical Case Reports",
    year = "2021",
    volume = "9",
    number = "4",
    pages = "2249-2253",
    publisher = "Wiley-Blackwell Publishing Ltd",
    issn = "2050-0904",
    doi = "10.1002/ccr3.4002",
    keywords = "azathioprine;  CD20 antigen;  CD23 antigen;  CD5 antigen;  CD79b antigen;  chlorambucil;  corticosteroid;  cyclophosphamide;  cyclosporine;  cytochrome P450 3A;  dexamethasone;  fludarabine;  ibrutinib;  idelalisib;  lactate dehydrogenase;  methotrexate;  petrafocon A HEM larafilcon A;  rituximab;  venetoclax, adult;  Article;  blood brain barrier;  bone marrow biopsy;  carcinomatous meningitis;  case report;  cell infiltration;  cerebrospinal fluid analysis;  chromosomal instability;  chromosome aberration;  chronic lymphatic leukemia;  clinical article;  cytogenetics;  female;  gene mutation;  human;  immunophenotyping;  middle aged;  nuclear magnetic resonance imaging;  Sanger sequencing;  splenomegaly",
    abstract = "Our unique case of Richter's Transformation presenting as leptomeningial infiltration in a CLL patient receiving venetoclax raises questions on whether the drug penetrates the blood-brain barrier and at what extend, especially in reduced doses given for drug-drug interactions. © 2021 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd."
}