@article{3103541, title = "Retinal Pigment Epithelial Detachment in Age-Related Macular Degeneration", author = "Karampelas, M. and Malamos, P. and Petrou, P. and Georgalas, I. and Papaconstantinou, D. and Brouzas, D.", journal = "Ophthalmology and Therapy", year = "2020", volume = "9", number = "4", pages = "739-756", publisher = "Adis", issn = "2193-6528", doi = "10.1007/s40123-020-00291-5", keywords = "aflibercept; bevacizumab; ranibizumab; vasculotropin; visual pigment, age related macular degeneration; atrophy; counseling; follow up; human; hydrophobicity; hydrostatic pressure; hyperpigmentation; indocyanine green angiography; low level laser therapy; microscopy; ophthalmoscopy; optical coherence tomography; pathophysiology; percutaneous coronary intervention; photodynamic therapy; pigment cell; priority journal; retina detachment; retina injury; retina neovascularization; retinal pigment epithelium; Review; slit lamp microscopy; subretinal fluid; visual acuity", abstract = "Retinal pigment epithelial detachment is defined as a separation of the retinal pigment epithelium from the inner collagenous layer of Bruch’s membrane. It is a common manifestation in both dry and wet types of age-related macular degeneration. This review aims to provide a comprehensive guide to the pathophysiology, clinical and imaging characteristics, natural course and treatment of the various types of pigment epithelial detachments in order to assist in diagnosis and management of this important feature of age-related macular degeneration. © 2020, The Author(s)." }