@article{3103985,
    title = "Call to Action: SARS-CoV-2 and CerebrovAscular DisordErs (CASCADE)",
    author = "Abootalebi, S. and Aertker, B.M. and Andalibi, M.S. and Asdaghi, N. and Aykac, O. and Azarpazhooh, M.R. and Bahit, M.C. and Barlinn, K. and Basri, H. and Shahripour, R.B. and Bersano, A. and Biller, J. and Borhani-Haghighi, A. and Brown, R.D. and Campbell, B.C. and Cruz-Flores, S. and De Silva, D.A. and Napoli, M.D. and Divani, A.A. and Edgell, R.C. and Fifi, J.T. and Ghoreishi, A. and Hirano, T. and Hong, K.-S. and Hsu, C.Y. and Huang, J.F. and Inoue, M. and Jagolino, A.L. and Kapral, M. and Kee, H.F. and Keser, Z. and Khatri, R. and Koga, M. and Krupinski, J. and Liebeskind, D.S. and Liu, L. and Ma, H. and Maud, A. and McCullough, L.D. and Meyer, D.M. and Mifsud, V. and Morovatdar, N. and Nilanont, Y. and Oxley, T.J. and Özdemir, A.Ö. and Pandian, J. and Pantoni, L. and Papamitsakis, N.I.H. and Parry-Jones, A. and Phan, T. and Rodriguez, G. and Romano, J.G. and Sabaa-Ayoun, Z. and Saber, H. and Sasannezhad, P. and Saver, J.L. and Scharf, E. and Shuaib, A. and Silver, B. and Singhal, S. and Smith, C.J. and Stranges, S. and Sylaja, P.N. and Torbey, M. and Toyoda, K. and Tsivgoulis, G. and Wasay, M. and Yassi, N. and Yoshimoto, T. and Zamani, B. and Zand, R.",
    journal = "Journal of Stroke and Cerebrovascular Diseases",
    year = "2020",
    volume = "29",
    number = "9",
    publisher = "W.B. Saunders",
    issn = "1052-3057",
    doi = "10.1016/j.jstrokecerebrovasdis.2020.104938",
    keywords = "Article;  brain hemorrhage;  brain ischemia;  cerebral sinus thrombosis;  cerebrovascular disease;  controlled study;  coronavirus disease 2019;  disease burden;  disease severity;  health care planning;  hospital mortality;  hospitalization;  human;  incidence;  neurosurgery;  outcome assessment;  priority journal;  prospective study;  retrospective study;  Severe acute respiratory syndrome coronavirus 2;  subarachnoid hemorrhage;  thrombectomy;  time series analysis;  Betacoronavirus;  cerebrovascular accident;  clinical practice;  clinical trial;  comorbidity;  comparative study;  Coronavirus infection;  health care disparity;  host pathogen interaction;  mortality;  multicenter study;  pandemic;  pathogenicity;  register;  risk factor;  time factor;  treatment outcome;  virology;  virus pneumonia, Betacoronavirus;  Comorbidity;  Coronavirus Infections;  Healthcare Disparities;  Hospital Mortality;  Hospitalization;  Host-Pathogen Interactions;  Humans;  Incidence;  Interrupted Time Series Analysis;  Pandemics;  Pneumonia, Viral;  Practice Patterns, Physicians';  Prospective Studies;  Registries;  Retrospective Studies;  Risk Factors;  Stroke;  Time Factors;  Treatment Outcome",
    abstract = "Background and purpose: The novel severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), now named coronavirus disease 2019 (COVID-19), may change the risk of stroke through an enhanced systemic inflammatory response, hypercoagulable state, and endothelial damage in the cerebrovascular system. Moreover, due to the current pandemic, some countries have prioritized health resources towards COVID-19 management, making it more challenging to appropriately care for other potentially disabling and fatal diseases such as stroke. The aim of this study is to identify and describe changes in stroke epidemiological trends before, during, and after the COVID-19 pandemic. Methods: This is an international, multicenter, hospital-based study on stroke incidence and outcomes during the COVID-19 pandemic. We will describe patterns in stroke management, stroke hospitalization rate, and stroke severity, subtype (ischemic/hemorrhagic), and outcomes (including in-hospital mortality) in 2020 during COVID-19 pandemic, comparing them with the corresponding data from 2018 and 2019, and subsequently 2021. We will also use an interrupted time series (ITS) analysis to assess the change in stroke hospitalization rates before, during, and after COVID-19, in each participating center. Conclusion: The proposed study will potentially enable us to better understand the changes in stroke care protocols, differential hospitalization rate, and severity of stroke, as it pertains to the COVID-19 pandemic. Ultimately, this will help guide clinical-based policies surrounding COVID-19 and other similar global pandemics to ensure that management of cerebrovascular comorbidity is appropriately prioritized during the global crisis. It will also guide public health guidelines for at-risk populations to reduce risks of complications from such comorbidities. © 2020"
}