@article{3105047,
    title = "Radiation therapy for the prevention of heterotopic ossification: Efficacy and toxicity of single fraction radiotherapy",
    author = "Georhakopoulos, I. and Kouloulias, V. and Kougiountzopoulou, A. and Platoni, K. and Antypas, C. and Liakouli, Z. and Nikoloudi, S. and Kelekis, N. and Moulopoulou, L.E. and Zygogianni, A.",
    journal = "Orthopedic Reviews",
    year = "2020",
    volume = "12",
    number = "2",
    pages = "90-94",
    publisher = "Page Press Publications",
    doi = "10.4081/or.2020.8577",
    keywords = "adult;  ankylosis;  Article;  bone radiography;  cancer mortality;  cancer radiotherapy;  carcinogenesis;  clinical article;  clinical target volume;  computer assisted tomography;  conformal radiotherapy;  drug efficacy;  drug toxicity;  follow up;  fracture nonunion;  heterotopic ossification;  human;  ionizing radiation;  knee function;  mesenchyme;  nuclear magnetic resonance imaging;  planning target volume;  radiation dose;  range of motion;  risk factor;  spine fusion;  wound healing;  young adult",
    abstract = "Numerous nonmalignant diseases can be treated with radiation therapy (RT). Among them, Heterotopic Ossification (HO) is a benign condition resulting from several causes that can be successfully managed with ionizing radiation. More often seen in the hip area after major surgical procedures, HO is of major concern as it can lead to functional disorders, pain and even to joint ankylosis. We retrospectively analyzed the outcome of therapeutic irradiation for the prevention of HO in 14 patients treated in our hospital between 2005 and 2011. All patients were irradiated with a dose ranging from 7 to10 Gy in a single fraction for prevention of HO after surgery. After a median follow up of 126 months (range 96 – 156 months) none of our patients developed HO. Impaired wound healing or other post surgery complications like trochanteric nonunion were not observed. A single fraction of RT seems to be a sufficient, cost effective and safe treatment regimen. In our study we report excellent results as none of our patients developed HO. © the Author(s), 2020 Licensee PAGEPress, Italy."
}