@article{3105431,
    title = "Pilonidal sinus disease: an intergluteal localization of hidradenitis suppurativa/acne inversa: a cross-sectional study among 2465 patients",
    author = "Benhadou, F. and Van der Zee, H.H. and Pascual, J.C. and Rigopoulos, D. and Katoulis, A. and Liakou, A.I. and Daxhelet, M. and Romanelli, M. and Iannone, M. and Kinyó, Á. and Nikolakis, G. and Zouboulis, C.C. and Dessinioti, C. and Zisimou, C. and Antoniou, C. and Alavi, A. and Mintoff, D. and Aquilina, S. and Matusiak, L. and Szepietowski, J.C. and Sinclair, R. and Husein-ElAhmed, H. and von Laffert, M. and Revuz, J. and Danby, B. and Puig, L. and Theut Riis, P. and Jemec, G.B.E. and van van Straalen, K. and Wigny, K.M.G.J. and del Marmol, V. and Guillem, P.",
    journal = "British Journal of Dermatology",
    year = "2019",
    volume = "181",
    number = "6",
    pages = "1198-1206",
    publisher = "Wiley-Blackwell Publishing Ltd",
    issn = "0007-0963, 1365-2133",
    doi = "10.1111/bjd.17927",
    keywords = "acne conglobata;  acne vulgaris;  adult;  anus;  Article;  buttock;  cohort analysis;  cross-sectional study;  disease association;  female;  folliculitis;  histopathology;  human;  human tissue;  inflammation;  major clinical study;  male;  pilonidal sinus;  prevalence;  priority journal;  psoriasis;  retrospective study;  suppurative hidradenitis;  clinical trial;  complication;  middle aged;  multicenter study;  pilonidal sinus;  risk factor;  suppurative hidradenitis;  young adult, Adult;  Buttocks;  Cross-Sectional Studies;  Female;  Hidradenitis Suppurativa;  Humans;  Male;  Middle Aged;  Pilonidal Sinus;  Prevalence;  Retrospective Studies;  Risk Factors;  Young Adult",
    abstract = "Background: Hidradenitis suppurativa (HS), also referred to as acne inversa, is a debilitating skin disease characterized by inflammatory nodules, chronic abscesses and tunnels (fistulae and sinuses). The association with pilonidal sinus disease (PSD) is frequently reported but not well documented. Objectives: To determine the prevalence and characteristics of inflammatory skin lesions located in the intergluteal fold (IGF) of patients with HS. Methods: This was an international multicentre retrospective cross-sectional study based on data collection from a large cohort of patients with HS with and without histopathology. Results From a total of 2465 patients with HS included in the study, 661 (27%) reported lesions in the IGF. These patients were significantly more often smokers and had more severe HS. Of the 238 patients with an available clinical diagnosis, intergluteal-HS (IG-HS) was diagnosed in 52 patients (22%) and PSD was diagnosed in 186 patients (78%). IG-HS was associated with the localization of HS in the proximity of the IGF, including the buttocks, genitals and the anus. There was a possibility of misclassification bias in this study as a clinical/image-based diagnosis or histopathology of the IGF lesions was not always available. Conclusions: The high prevalence of PSD suggests a strong link between both entities. Therefore, it may be useful to identify common pathophysiological mechanisms and develop common therapeutic strategies. What's already known about this topic?. The occurrence of pilonidal sinus disease has not been clearly reported among patients with hidradenitis suppurativa/acne inversa. What does this study add?. This is the first study that investigated the prevalence of pilonidal sinus disease among a large cohort of patients and identified the patient characteristics. Risk factors that might help to improve the management of patients were identified. © 2019 British Association of Dermatologists"
}