@article{3105560,
    title = "Past history of stage I/II solid tumor malignancy impacts considerably on sepsis mortality: A propensity score matching analysis from the hellenic sepsis study group",
    author = "Dimpoulos, G. and Rovina, N. and Patrani, M. and Antoniadou, E. and Konstantonis, D. and Vryza, K. and Vlachogianni, G. and Kyprianou, M. and Routsi, C. and Giamarellos-Bourboulis, E.J.",
    journal = "BMC Infectious Diseases",
    year = "2019",
    volume = "19",
    number = "1",
    publisher = "BioMed Central Ltd.",
    issn = "1471-2334",
    doi = "10.1186/s12879-019-4448-7",
    keywords = "procalcitonin;  urokinase receptor, adult;  age;  aged;  Article;  cancer regression;  cancer staging;  clinical outcome;  comorbidity;  controlled study;  disease classification;  disease severity;  female;  hospital admission;  human;  independent variable;  intensive care unit;  ischemic heart disease;  kidney injury;  major clinical study;  male;  medical history;  middle aged;  mortality;  propensity score;  protein blood level;  risk factor;  sepsis;  septic shock;  solid malignant neoplasm;  acute kidney failure;  cancer staging;  complication;  coronary artery disease;  neoplasm;  odds ratio;  pathology;  propensity score;  proportional hazards model;  sepsis;  very elderly, Acute Kidney Injury;  Aged;  Aged, 80 and over;  Coronary Disease;  Female;  Humans;  Intensive Care Units;  Male;  Middle Aged;  Neoplasm Staging;  Neoplasms;  Odds Ratio;  Propensity Score;  Proportional Hazards Models;  Risk Factors;  Sepsis;  Shock, Septic",
    abstract = "Background: Whether past history of solid stage I/II inactive cancer has an impact on 28-day mortality of sepsis remains unclear. We aimed to determine the impact of history of stage I or II solid tumor malignancy in complete remission the last 3 years on sepsis outcome. Methods: Using the database of the Hellenic Sepsis Study Group from 1553 patients with sepsis admitted in the ICU, 83 patients with sepsis by Sepsis-3 definition with past-history of stage I/II inactive solid malignancy the last 3 years were depicted. A comparator group of 83 patients fully matched for age, severity, type of infection and comorbidities was selected by propensity score matching. Results: Mortality after 28 days was 37.3% in the comparator group and 54.2% in the solid tumor stage I/II group (odds ratio for death 1.98; p: 0.030). Following step-wise forward Cox regression analysis, septic shock (hazard ratio 1.80), acute renal injury (hazard ratio 2.06), history of coronary heart disease (hazard ratio 0.36) and history of stage I/II solid tumor malignancy (hazard ratio 1.79) were the only independent variables associated with 28-day mortality. Serum levels of procalcitonin and of soluble urokinase plasminogen activator receptor were similar between the two groups of comparisons. Conclusions: Past history of stage I/II solid malignancy is an independent risk factor for unfavorable outcome from sepsis the first 28 days. © 2019 The Author(s)."
}