@article{3106394,
    title = "Prognostic role of microRNAs in breast cancer: A systematic review",
    author = "Zografos, E. and Zagouri, F. and Kalapanida, D. and Zakopoulou, R. and Kyriazoglou, A. and Apostolidou, K. and Gazouli, M. and Dimopoulos, M.-A.",
    journal = "OncoTargets and therapy",
    year = "2019",
    volume = "10",
    number = "67",
    pages = "7156-7178",
    publisher = "Impact Journals, LLC",
    doi = "10.18632/oncotarget.27327",
    keywords = "microRNA;  microRNA 1;  microRNA 10b;  microRNA 125b;  microRNA 15a;  microRNA 16;  microRNA 19a;  microRNA 19b;  microRNA 200b;  microRNA 203;  microRNA 20b 5p;  microRNA 21;  microRNA 210;  microRNA 22;  microRNA 24 3p;  microRNA 27a;  microRNA 27b 3p;  microRNA 29a;  microRNA 29b;  microRNA 30a;  microRNA 30a 3p;  microRNA 30a 5p;  microRNA 30c 5p;  microRNA 30e;  microRNA 34a;  microRNA 375;  microRNA 7;  microRNA 9;  phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase;  unclassified drug;  unindexed drug, angiogenesis;  Article;  breast cancer;  cancer prognosis;  cancer staging;  cell cycle regulation;  disease free survival;  DNA repair;  down regulation;  epithelial mesenchymal transition;  high throughput sequencing;  human;  human epidermal growth factor receptor 2 positive breast cancer;  immune response;  immunohistochemistry;  in situ hybridization;  locked nucleic acid probe in situ hybridization;  luciferase assay;  luminal A breast cancer;  luminal B breast cancer;  lymph node metastasis;  microarray analysis;  mitochondrial respiration;  MTS assay;  MTT assay;  outcome assessment;  overall survival;  progression free survival;  protein expression;  real time reverse transcription polymerase chain reaction;  recurrence free survival;  systematic review;  triple negative breast cancer;  tumor suppressor gene;  upregulation;  Western blotting",
    abstract = "MicroRNAs (miRNAs) have been found to play an important role in breast cancer, functioning either as potential oncogenes or tumor suppressor genes, but their role in the prognosis of patients remains unclear. The aim of the present review study is to highlight recent preclinical and clinical studies performed on both circulating and tissue-specific miRNAs and their potential role as prognostic markers in breast cancer. We systematically searched the PubMed database to explore the prognostic value of miRNAs in breast cancer. After performing the literature search and review, 117 eligible studies were identified. We found that 110 aberrantly expressed miRNAs have been associated with prognosis in breast cancer. In conclusion, the collective data presented in this review indicate that miRNAs could serve as novel prognostic tools in breast cancer, while the clinical application of these findings has yet to be verified. Copyright: © Zografos et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0)."
}