@article{3106658,
    title = "ALBI and PALBI grades are associated with the outcome of patients with stable decompensated cirrhosis",
    author = "Oikonomou, T. and Goulis, I. and Doumtsis, P. and Tzoumari, T. and Akriviadis, E. and Cholongitas, E.",
    journal = "Annals of Hepatology",
    year = "2019",
    volume = "18",
    number = "1",
    pages = "126-136",
    publisher = "Fundacion Clinica Medica Sur",
    doi = "10.5604/01.3001.0012.7904",
    keywords = "bilirubin;  serum albumin;  albumin-bilirubin complex;  bilirubin;  biological marker;  human serum albumin, adolescent;  adult;  aged;  albumin bilirubin grade;  albumin blood level;  Article;  bacterial peritonitis;  bilirubin blood level;  Child Pugh score;  clinical feature;  clinical outcome;  comparative study;  controlled study;  decompensated liver cirrhosis;  disease association;  disease severity;  female;  follow up;  gastrointestinal hemorrhage;  hepatic encephalopathy;  human;  human cell;  laboratory test;  liver transplantation;  major clinical study;  male;  middle aged;  Model For End Stage Liver Disease Score;  mortality;  platelet count;  prediction;  prognosis;  prospective study;  receiver operating characteristic;  scoring system;  survival time;  young adult;  blood;  disease exacerbation;  epidemiology;  Greece;  liver cirrhosis;  pathology;  platelet count;  predictive value;  severity of illness index;  survival rate;  thrombocyte, Adolescent;  Adult;  Aged;  Bilirubin;  Biomarkers;  Blood Platelets;  Disease Progression;  Female;  Follow-Up Studies;  Greece;  Humans;  Liver Cirrhosis;  Male;  Middle Aged;  Platelet Count;  Predictive Value of Tests;  Prognosis;  Prospective Studies;  Serum Albumin, Human;  Severity of Illness Index;  Survival Rate;  Young Adult",
    abstract = "Introduction and aim. Studies carried out mainly in patients with hepatocellular carcinoma (HCC), have shown the prognostic significance of albumin-bilirubin (ALBI) grade. Recently, another predictive score incorporating platelet count into ALBI, PALBI grade, was introduced in patients with HCC. Aim. We evaluated the ability of ALBI and PALBI grades in predicting the outcome (mortality / liver transplantation) of patients with stable decompensated cirrhosis with various etiology of liver diseases. Material and methods. We prospectively studied 325 patients with stable decompensated cirrhosis awaiting liver transplantation. Their clinical and laboratory characteristics were recorded including albumin, bilirubin levels, platelets. We estimated ALBI and PALBI grades for every patient. Conventional prognostic scores were also evaluated; Child-Pugh (CTP), Model for End stage Liver Disease (MELD). We followed them up and recorded their outcome. Results. Beyond MELD and CTP, ALBI and PALBI grades proved significant factors associated with the outcome (HR: 2.13, 95%CI [1.59, 2.85], p < 0.001 and HR: 2.06, 95%CI [1.47, 2.9], p < 0.001, respectively), and their predictive capability was established (ROC analysis; AUC: 0.695, 95% CI [0.634, 0.755] and AUC: 0.683, 95% CI [0.621, 0.744], respectively). ALBI and PALBI performed better than CTP score (p = 0.0044 and p = 0.014, respectively). Categorization of our patients into three ALBI groups detected statistically different survival times. Accordingly, PALBI grade 3 compared to those with PALBI grade 1 and 2 patients, had worse outcome and significantly higher frequency of cirrhosis-related complications. Conclusions. ALBI and PALBI grades were validated and can be used to predict the outcome in patients with stable decompensated cirrhosis. © 2019, Fundacion Clinica Medica Sur. All rights reserved."
}