@article{3106694,
    title = "The impact of apelin and relaxin plasma levels in masked hypertension and white coat hypertension",
    author = "Sanidas, E. and Tsakalis, K. and Papadopoulos, D.P. and Zerva, K. and Velliou, M. and Perrea, D. and Mantzourani, M. and Iliopoulos, D. and Barbetseas, J.",
    journal = "The Journal of Clinical Hypertension",
    year = "2019",
    volume = "21",
    number = "1",
    pages = "48-52",
    publisher = "Blackwell Publishing Inc.",
    issn = "1524-6175, 1751-7176",
    doi = "10.1111/jch.13449",
    keywords = "apelin;  relaxin;  adipocytokine;  apelin;  relaxin, adult;  Article;  blood pressure monitoring;  controlled study;  enzyme linked immunosorbent assay;  female;  hormone blood level;  human;  major clinical study;  male;  masked hypertension;  priority journal;  prognosis;  protein blood level;  white coat hypertension;  atherosclerosis;  blood;  cardiovascular disease;  comparative study;  complication;  cross-sectional study;  essential hypertension;  masked hypertension;  metabolism;  middle aged;  pathophysiology;  prevalence;  procedures;  risk factor;  white coat hypertension, Adipokines;  Adult;  Apelin;  Atherosclerosis;  Blood Pressure Monitoring, Ambulatory;  Cardiovascular Diseases;  Cross-Sectional Studies;  Essential Hypertension;  Female;  Humans;  Male;  Masked Hypertension;  Middle Aged;  Prevalence;  Prognosis;  Relaxin;  Risk Factors;  White Coat Hypertension",
    abstract = "Masked hypertension (HTN) and white coat hypertension represent two reverse forms of clinical HTN with questionable prognostic significance. Recent evidence supports that low apelin and relaxin plasma levels contribute to vascular damage accelerating atherogenesis and predisposing to HTN and cardiovascular (CV) events. The aim of this study was to compare apelin and relaxin plasma levels between patients with masked hypertension (MH) and those with white coat HTN (WCH). Overall, 130 patients not receiving antihypertensive therapy were studied. All patients underwent 24-hour ambulatory BP monitoring (ABPM) and office BP measurements. Plasma apelin and relaxin levels were measured by ELISA method. According to BP recordings, 24 subjects had MH (group A) and 32 had WCH (group B). Apelin (200 ± 111 pg/mL vs 305 ± 127 pg/mL, P < 0.01) and relaxin (35.2 ± 6.7 pg/mL vs 46.8 ± 23.6 pg/mL, P < 0.01) plasma levels were significantly lower in patients with MH compared to those with WCH, respectively. In conclusion, our findings showed that patients with MH had significantly lower apelin and relaxin levels compared to those with WCH. This observation implies an additional prognostic role for adipokines supporting the concept that MH is closer to essential HTN whereas WCH is a more benign condition. ©2018 Wiley Periodicals, Inc."
}