@article{3107331,
    title = "Inflammation associates with impaired small arterial elasticity early in HIV disease",
    author = "Peterson, T.E. and Hullsiek, K.H. and Engen, N.W. and Kumarasamy, N. and Lebech, A.-M. and Liappis, A. and Papadopoulos, A. and Polizzotto, M.N. and Schreiner, P.J. and Duprez, D. and Baker, J.V. and INSIGHT START (Strategic Timing of AntiRetroviral Treatment) Study Group",
    journal = "Open Forum Infectious Diseases",
    year = "2018",
    volume = "5",
    number = "6",
    publisher = "Oxford University Press",
    issn = "2328-8957",
    doi = "10.1093/ofid/ofy117",
    keywords = "adiponectin;  biological marker;  C reactive protein;  cholesterol;  hemoglobin A1c;  high density lipoprotein cholesterol;  intercellular adhesion molecule 1;  interleukin 27;  interleukin 6;  interleukin 8;  low density lipoprotein cholesterol;  serum amyloid A;  triacylglycerol;  tumor necrosis factor, adult;  antiinflammatory activity;  antiretroviral therapy;  arterial pressure;  Article;  body mass;  CD4 lymphocyte count;  clinical trial (topic);  cross-sectional study;  elasticity;  enzyme linked immunosorbent assay;  fluorescence analysis;  Hospital Anxiety and Depression Scale;  human;  Human immunodeficiency virus infection;  hypertension;  inflammation;  major clinical study;  male;  physical activity;  priority journal;  radial artery;  tonometry;  virus load",
    abstract = "We estimated small arterial elasticity and used linear regression to evaluate its association with inflammatory biomarkers among antiretroviral therapy-naïve, HIV-positive patients with high CD4+ counts. After adjustment, high-sensitivity C-reactive protein and interleukin-6 were inversely associated with small arterial elasticity. These data suggest that systemic inflammation may contribute to vascular dysfunction even in very early HIV disease. © The Author(s) 2018."
}