@article{3107393,
    title = "Korsakoffsyndrome in non-alcoholic psychiatric patients. Variable cognitive presentation and impaired frontotemporal connectivity",
    author = "Nikolakaros, G. and Kurki, T. and Paju, J. and Papageorgiou, S.G. and Vataja, R. and Ilonen, T.",
    journal = "FRONTIERS IN PSYCHIATRY",
    year = "2018",
    volume = "9",
    number = "MAY",
    publisher = "Frontiers Media S.A",
    doi = "10.3389/fpsyt.2018.00204",
    keywords = "agomelatine;  citalopram;  flupentixol;  lamotrigine;  moclobemide;  modafinil;  paroxetine;  sertraline;  thyroid hormone;  tianeptine;  valproic acid, adult;  Article;  attention disturbance;  case report;  cingulum (brain);  clinical article;  clinical feature;  cognitive defect;  corpus callosum;  depression;  diffusion tensor imaging;  executive function;  female;  fractional anisotropy;  human;  hypothyroidism;  Korsakoff psychosis;  male;  memory disorder;  memory test;  mental patient;  neuropsychological test;  nuclear magnetic resonance imaging;  psychomotor disorder;  radiodiagnosis;  uncinate fasciculus;  verbal memory;  Wernicke encephalopathy;  white matter lesion;  word list recall;  working memory",
    abstract = "Background: Non-alcoholic Wernicke's encephalopathy and Korsakoffsyndrome are greatly underdiagnosed. There are very few reported cases of neuropsychologically documented non-alcoholic Korsakoffsyndrome, and diffusion tensor imaging (DTI) data are scarce. Methods: We report clinical characteristics and neuropsychological as well as radiological findings from three psychiatric patients (one woman and two men) with a history of probable undiagnosed non-alcoholic Wernicke's encephalopathy and subsequent chronic memory problems. Results: All patients had abnormal neuropsychological test results, predominantly in memory. Thus, the neuropsychological findings were compatible with Korsakoffsyndrome. However, the neuropsychological findings were not uniform. The impairment of delayed verbal memory of the first patient was evident only when the results of the memory tests were compared to her general cognitive level. In addition, the logical memory test and the verbal working memory test were abnormal, but the word list memory test was normal. The second patient had impaired attention and psychomotor speed in addition to impaired memory. In the third patient, the word list memory test was abnormal, but the logical memory test was normal. All patients had intrusions in the neuropsychological examination. Executive functions were preserved, except for planning and foresight, which were impaired in two patients. Conventional MRI examination was normal. DTI showed reduced fractional anisotropy values in the uncinate fasciculus in two patients, and in the corpus callosum and in the subgenual cingulum in one patient. Conclusions: Non-alcoholic Korsakoffsyndrome can have diverse neuropsychological findings. This may partly explain its marked underdiagnosis. Therefore, a strong index of suspicion is needed. The presence of intrusions in the neuropsychological examination supports the diagnosis. Damage in frontotemporal white matter tracts, particularly in the uncinate fasciculus, may be a feature of non-alcoholic Korsakoffsyndrome in psychiatric patients. © 2018 Nikolakaros, Kurki, Paju, Papageorgiou, Vataja and Ilonen."
}