@article{3107944,
    title = "A comparative assessment of inhomogeneity and finite patient dimension effects in 60Co and 192Ir high-dose-rate brachytherapy",
    author = "Fotina, I. and Zourari, K. and Lahanas, V. and Pantelis, E. and Papagiannis, P.",
    journal = "Journal of Contemporary Brachytherapy",
    year = "2018",
    volume = "10",
    number = "1",
    pages = "73-84",
    publisher = "Termedia Publishing House Ltd.",
    doi = "10.5114/jcb.2018.74327",
    keywords = "cobalt 60;  iridium 192, algorithm;  Article;  brachytherapy;  breast cancer;  comparative study;  computer simulation;  digital imaging and communications in medicine;  dose homogeneity index;  dosimetry;  esophagus cancer;  finite patient dimension effect;  high dose rate brachytherapy;  human;  Monte Carlo method;  organs at risk;  patient specific simulation;  radiation dose distribution;  radiation related phenomena;  radiological parameters;  retrospective study;  simulation;  single source simulation;  tissue inhomogeneity;  treatment planning;  uterine cervix cancer",
    abstract = "Purpose: To perform a comparative study of heterogeneities and finite patient dimension effects in 60Co and 192Ir high-dose-rate (HDR) brachytherapy. Material and methods: Clinically equivalent plans were prepared for 19 cases (8 breast, 5 esophagus, 6 gynecologic) using the Ir2.A85-2 and the Co0.A86 HDR sources, with a TG-43 based treatment planning system (TPS). Phase space files were obtained for the two source designs using MCNP6, and validated through comparison to a single source dosimetry results in the literature. Dose to water, taking into account the patient specific anatomy and materials (Dw,m), was calculated for all plans using MCNP6, with input files prepared using the BrachyGuide software tool to analyze information from DICOM RT plan exports. Results: A general TG-43 dose overestimation was observed, except for the lungs, with a greater magnitude for 192Ir. The distribution of percentage differences between TG-43 and Monte Carlo (MC) in dose volume histogram (DVH) indices for the planning target volume (PTV) presented small median values (about 2%) for both 60Co and 192Ir, with a greater dispersion for 192Ir. Regarding the organs at risk (OARs), median percentage differences for breast V50% were 3% (5%) for 60Co (192Ir). Differences in median skin D2cc were found comparable, with a larger dispersion for 192Ir, and the same applied to the lung D10cc and the aorta D2cc. TG-43 overestimates D2cc for the rectum and the sigmoid, with median differences from MC within 2% and a greater dispersion for 192Ir. For the bladder, the median of the difference is greater for 60Co (∼2%) than for 192Ir (∼0.75%), demonstrating however a greater dispersion again for 192Ir. Conclusions: The magnitude of differences observed between TG-43 based and MC dosimetry and their smaller dispersion relative to 192Ir, suggest that 60Co HDR sources are more amenable to the TG-43 assumptions in clinical treatment planning dosimetry. © J Contemp Brachytherapy 2018."
}