@article{3108695,
    title = "Addressing unmet needs in understanding asthma mechanisms",
    author = "Edwards, M.R. and Saglani, S. and Schwarze, J. and Skevaki, C. and Smith, J.A. and Ainsworth, B. and Almond, M. and Andreakos, E. and Belvisi, M.G. and Chung, K.F. and Cookson, W. and Cullinan, P. and Hawrylowicz, C. and Lommatzsch, M. and Jackson, D. and Lutter, R. and Marsland, B. and Moffatt, M. and Thomas, M. and Virchow, J.C. and Xanthou, G. and Edwards, J. and Walker, S. and Johnston, S.L. and Adcock, I. and Akdis, C. and Bel, E. and Bousquet, J. and Ten Brinke, A. and Brusselle, G. and Dáhlen, S.-E. and Djukanovic, R. and Gaga, M. and Garcia-Marcos, L. and Hiemstra, P. and Heffler, E. and Holgate, S. and Kupczyk, M. and Lloyd, C. and Lucas, J. and Magnan, A. and Martin, T. and Myles, D. and Page, C. and Palkonen, S. and Papadopoulos, N. and Papi, A. and Powell, P. and Riley, J. and Sayers, I. and Spanevello, A. and Sterk, P. and Xepapadaki, P. and Wheelock, .C. and members of the EARIP WP2 working group12",
    journal = "The European respiratory journal",
    year = "2017",
    volume = "49",
    number = "5",
    publisher = "European Respiratory Society",
    doi = "10.1183/13993003.02448-2016",
    keywords = "allergen;  beta 2 adrenergic receptor stimulating agent;  corticosteroid;  fenoterol;  hormone;  leukotriene receptor blocking agent, air pollution;  asthma;  bacterial infection;  behavior;  Churg Strauss syndrome;  diet;  disease course;  disease exacerbation;  genome-wide association study;  human;  immunological tolerance;  immunoreactivity;  lipidomics;  lung function;  metabolomics;  microbiome;  Mycobacterium tuberculosis;  nonhuman;  pathogenesis;  Pneumovirus;  practice guideline;  priority journal;  respiratory tract inflammation;  Review;  social psychology;  Th2 cell;  virus infection;  whole exome sequencing;  asthma;  consensus development;  disease exacerbation;  economics;  Europe;  medical research;  needs assessment;  pathophysiology;  trends, Asthma;  Biomedical Research;  Consensus Development Conferences as Topic;  Disease Progression;  Europe;  Humans;  Needs Assessment",
    abstract = "Asthma is a heterogeneous, complex disease with clinical phenotypes that incorporate persistent symptoms and acute exacerbations. It affects many millions of Europeans throughout their education and working lives and puts a heavy cost on European productivity. There is a wide spectrum of disease severity and control. Therapeutic advances have been slow despite greater understanding of basic mechanisms and the lack of satisfactory preventative and disease modifying management for asthma constitutes a significant unmet clinical need. Preventing, treating and ultimately curing asthma requires co-ordinated research and innovation across Europe. The European Asthma Research and Innovation Partnership (EARIP) is an FP7-funded programme which has taken a co-ordinated and integrated approach to analysing the future of asthma research and development. This report aims to identify the mechanistic areas in which investment is required to bring about significant improvements in asthma outcomes. Copyright ©ERS 2017."
}