@article{3109068,
    title = "The effect of the antioxidant drug U-74389G on urea levels during ischemia reperfusion injury in rats",
    author = "Tsompos, C. and Panoulis, C. and Toutouzas, K. and Triantafyllou, A. and Zografos, G. and Papalois, A.",
    journal = "Italian Journal of Medicine",
    year = "2017",
    volume = "11",
    number = "3",
    pages = "305-309",
    publisher = "Page Press Publications",
    issn = "1877-9344",
    doi = "10.4081/itjm.2017.719",
    keywords = "21 [4 [2,6 bis(1 pyrrolidinyl) 4 pyrimidinyl] 1 piperazinyl]pregna 1,4,9(11) triene 3,20 dione;  acid phosphatase;  alkaline phosphatase;  calcium ion;  chloride ion;  creatine kinase;  glucose;  hemoglobin;  magnesium ion;  phosphate;  protein;  sodium ion;  urea, acid phosphatase blood level;  alkaline phosphatase blood level;  animal experiment;  antioxidant activity;  Article;  body mass;  calcium blood level;  chloride blood level;  controlled study;  creatine kinase blood level;  erythrocyte count;  female;  glucose blood level;  hematocrit;  hemoglobin blood level;  hemoglobin determination;  leukocyte count;  magnesium blood level;  mean cell hemoglobin;  mean cell hemoglobin concentration;  nonhuman;  phosphate blood level;  platelet distribution width;  protein blood level;  rat;  red blood cell distribution width;  reperfusion injury;  sodium blood level;  thrombocyte count;  urea blood level",
    abstract = "This experimental study examined the effect of the antioxidant drug U-74389G, on a rat model and particularly in a renal ischemia- reperfusion protocol. The effects of that molecule were studied biochemically using blood mean urea levels. Forty rats of mean weight 231.875 g were used in the study. Urea levels were measured at 60 min of reperfusion (groups A and C) and at 120 min of reperfusion (groups B and D). The drug U-74389G was administered only in groups C and D. U-74389G administration significantly decreased the predicted urea levels by 11.35%±2.73% (P=0.0001). Reperfusion time non-significantly increased the predicted urea levels by 2.26%±3.29% (P=0.4103). However, U-74389G administration and reperfusion time together significantly decreased the predicted urea levels by 6.31%±1.70% (P=0.0005). U-74389G administration whether it interacted or not with reperfusion time had significant decreasing effect on the urea serum levels, reflecting a respective renal function augmentation. © Copyright C. ?sompos et al., 2017 Licensee PAGE Press."
}