@article{3109803,
    title = "-572 G/C single nucleotide polymorphism of interleukin-6 and sepsis predisposition in chronic renal disease",
    author = "Panayides, A. and Ioakeimidou, A. and Karamouzos, V. and Antonakos, N. and Koutelidakis, I. and Giannikopoulos, G. and Makaritsis, K. and Voloudakis, N. and Toutouzas, K. and Rovina, N. and Bristianou, M. and Damoraki, G. and Routsi, C. and Giamarellos-Bourboulis, E.J.",
    journal = "European Journal of Clinical Microbiology and Infectious Diseases",
    year = "2015",
    volume = "34",
    number = "12",
    pages = "2439-2446",
    publisher = "Springer-Verlag",
    doi = "10.1007/s10096-015-2500-0",
    keywords = "interleukin 6;  IL6 protein, human;  interleukin 6, adult;  aged;  Article;  chronic kidney disease;  controlled study;  death;  disease predisposition;  end stage renal disease;  enzyme immunoassay;  female;  frequency;  gene frequency;  genotype;  human;  logistic regression analysis;  major clinical study;  male;  mortality;  priority journal;  restriction fragment length polymorphism;  sepsis;  single nucleotide polymorphism;  systemic inflammatory response syndrome;  adolescent;  blood;  chronic kidney failure;  clinical trial;  complication;  enzyme linked immunosorbent assay;  genetic predisposition;  genetics;  genotyping technique;  middle aged;  multicenter study;  prospective study;  regulatory sequence;  sepsis;  survival analysis;  very elderly;  young adult, Adolescent;  Adult;  Aged;  Aged, 80 and over;  Enzyme-Linked Immunosorbent Assay;  Genetic Predisposition to Disease;  Genotyping Techniques;  Humans;  Interleukin-6;  Middle Aged;  Polymorphism, Restriction Fragment Length;  Polymorphism, Single Nucleotide;  Prospective Studies;  Regulatory Elements, Transcriptional;  Renal Insufficiency, Chronic;  Sepsis;  Survival Analysis;  Young Adult",
    abstract = "Single nucleotide polymorphisms (SNPs) of interleukin (IL)-6 are associated with the development of chronic renal disease (CRD). Their impact for sepsis in the field of CRD was investigated. One control cohort of 115 patients with CRD without infection and another case cohort of 198 patients with CRD and sepsis were enrolled. Genotyping at the −174 (rs1800795) and −572 positions of IL-6 (rs1800796) was done by restriction fragment length polymorphism. Circulating IL-6 was measured by an enzyme immunoassay. The GG genotype of rs1800796 was more frequent among cases (78.3 %) than controls (62.6 %). No difference in the genotype frequencies of rs1800795 between cases and controls were found. Odds ratio for sepsis was 2.07 (95%CI 1.24–3.44, p = 0.005) with the GG genotype of rs1800796, which was confirmed by logistic regression analysis taking into consideration the presence of chronic comorbidities. All-cause mortality until day 28 was similar between patients with the GG genotype and the GC/CC genotypes of rs1800796, but death caused from cardiovascular events not-related with infection was more frequent with the GG genotype (14.6 % vs 2.4 %, p = 0.031). Circulating IL-6 was greater among patients of the GC/CC genotypes of rs1800796 and multiple organ dysfunction (p = 0.013). The GG genotype of rs1800796 predisposes to sepsis in CRD and to 28-day mortality by sepsis-unrelated cardiovascular phenomena. © 2015, Springer-Verlag Berlin Heidelberg."
}