@article{3111630,
    title = "A sex-specific association between a 15q25 variant and upper aerodigestive tract cancers",
    author = "Chen, D. and Truong, T. and Gaborieau, V. and Byrnes, G. and Chabrier, A. and Chuang, S.-C. and Olshan, A.F. and Weissler, M.C. and Luo, J. and Romkes, M. and Buch, S. and Nukui, T. and Franceschi, S. and Herrero, R. and Talamini, R. and Kelsey, K.T. and Christensen, B. and McClean, M.D. and Lacko, M. and Manni, J.J. and Peters, W.H.M. and Lubiński, J. and Trubicka, J. and Lener, M. and Muscat, J.E. and Lazarus, P. and Wei, Q. and Sturgis, E.M. and Zhang, Z.-F. and Chang, S.-C. and Wang, R. and Schwartz, S.M. and Chen, C. and Benhamou, S. and Lagiou, P. and Holcátová, I. and Richiardi, L. and Kjaerheim, K. and Agudo, A. and Castellsagué, X. and Macfarlane, T.V. and Barzan, L. and Canova, C. and Thakker, N.S. and Conway, D.I. and Znaor, A. and Healy, C.M. and Ahrens, W. and Zaridze, D. and Szeszenia-Dabrowska, N. and Lissowska, J. and Fabianova, E. and Bucur, A. and Bencko, V. and Foretova, L. and Janout, V. and Curado, M.P. and Koifman, S. and Menezes, A. and Wünsch-Filho, V. and Eluf-Neto, J. and Fernandez, L. and Boccia, S. and Hashibe, M. and Hayes, R.B. and Boffetta, P. and Brennan, P. and McKay, J.D.",
    journal = "Cancer Epidemiology Biomarkers and Prevention",
    year = "2011",
    volume = "20",
    number = "4",
    pages = "658-664",
    doi = "10.1158/1055-9965.EPI-10-1008",
    keywords = "adult;  aged;  alcohol consumption;  article;  cancer risk;  case control study;  chromosome 15q;  cigarette smoking;  controlled study;  digestive system cancer;  esophagus cancer;  female;  genetic association;  genetic variability;  genotype;  heterozygote;  human;  hypopharynx cancer;  larynx cancer;  major clinical study;  male;  mouth cancer;  oropharynx cancer;  priority journal;  sex difference;  single nucleotide polymorphism;  upper aerodigestive tract cancer, Aged;  Aged, 80 and over;  Americas;  Case-Control Studies;  Chromosomes, Human, Pair 15;  Europe;  Female;  Genotype;  Head and Neck Neoplasms;  Humans;  Male;  Middle Aged;  Sex Factors;  Smoking",
    abstract = "Background: Sequence variants located at 15q25 have been associated with lung cancer and propensity to smoke. We recently reported an association between rs16969968 and risk of upper aerodigestive tract (UADT) cancers (oral cavity, oropharynx, hypopharynx, larynx, and esophagus) in women (OR = 1.24, P = 0.003) with little effect in men (OR = 1.04, P = 0.35). Methods: In a coordinated genotyping study within the International Head and Neck Cancer Epidemiology (INHANCE) consortium, we have sought to replicate these findings in an additional 4,604 cases and 6,239 controls from 10 independent UADT cancer case - control studies. Results: rs16969968 was again associated with UADT cancers in women (OR = 1.21, 95% CI = 1.08-1.36, P = 0.001) and a similar lack of observed effect in men [OR = 1.02, 95% CI = 0.95-1.09, P = 0.66; P-heterogeneity (P het) = 0.01]. In a pooled analysis of the original and current studies, totaling 8,572 UADT cancer cases and 11,558 controls, the association was observed among females (OR = 1.22, 95% CI = 1.12-1.34, P = 7 × 10 -6) but not males (OR = 1.02, 95% CI = 0.97-1.08, P = 0.35; P het = 6 × 10-4). There was little evidence for a sex difference in the association between this variant and cigarettes smoked per day, with male and female rs16969968 variant carriers smoking approximately the same amount more in the 11,991 ever smokers in the pooled analysis of the 14 studies (Phet = 0.86). Conclusions: This study has confirmed a sex difference in the association between the 15q25 variant rs16969968 and UADT cancers. Impact: Further research is warranted to elucidate the mechanisms underlying these observations.©2011 AACR."
}