@article{3111787,
    title = "The significance of survivin and nectin-4 expression in the prognosis of breast carcinoma",
    author = "Athanassiadou, A.M. and Patsouris, E. and Tsipis, A. and Gonidi, M. and Athanassiadou, P.",
    journal = "Folia Histochemica et Cytobiologica",
    year = "2011",
    volume = "49",
    number = "1",
    pages = "26-33",
    publisher = "Via Medica SP Zoo",
    issn = "0239-8508, 1897-5631",
    doi = "10.5603/FHC.2011.0005",
    keywords = "antiestrogen;  cell adhesion molecule;  cyclophosphamide;  doxorubicin;  nectin 4;  paclitaxel;  survivin;  unclassified drug, adult;  aged;  article;  breast carcinoma;  breast surgery;  cancer grading;  cancer patient;  cancer size;  cancer survival;  controlled study;  female;  histopathology;  human;  human tissue;  immunocytochemistry;  lymph node metastasis;  major clinical study;  multiple cycle treatment;  prognosis;  protein analysis;  protein expression;  smear;  survival time",
    abstract = "To investigate the prognostic significance of Survivin and Nectin-4 expression in breast carcinomas. Imprint smears were obtained from 140 breast carcinoma specimens and studied immunocytochemically for the expression of Survivin and Nectin-4. The results were correlated with several clinicopathological parameters, including five-year survival. Increased Survivin staining pattern correlated with increased grade (p< 0.0001), increased lymph node invasion (p< 0.0001), increased tumor size and reduced survival (p< 0.0001). Elevated Nectin-4 expression also correlated significantly with increased grade (p< 0.0001), increased tumor size (p< 0.0001) and reduced survival (p< 0.0001). In addition, Survivin and Nectin-4 staining patterns correlated strongly with one another (p< 0.0001). However, on multivariate analysis, neither Survivin nor Nectin-4 expression seemed to have an independent impact on survival in our study cases. The findings of our study suggest that increased expression of Survivin and Nectin-4 may indicate a worse prognosis in breast cancer patients. The exact implications of the expression of these markers in breast cancer prognosis and treatment remain to be clarified. © Polish Society for Histochemistry and Cytochemistry."
}