@article{3112731,
    title = "Abrupt and durable remission of Henoch-Schönlein purpura nephritis with cyclosporine A",
    author = "Georgaki-Angelaki, E. and Kostaridou, S. and Lourida, A. and Petraki, C. and Lagona, E.",
    journal = "NDT Plus",
    year = "2008",
    volume = "1",
    number = "5",
    pages = "300-302",
    issn = "1753-0784, 1753-0792",
    doi = "10.1093/ndtplus/sfn105",
    keywords = "azathioprine;  cyclophosphamide;  cyclosporin A;  methylprednisolone;  prednisolone, add on therapy;  anaphylactoid purpura;  article;  case report;  disease association;  drug blood level;  drug dose reduction;  drug withdrawal;  female;  follow up;  glomerulonephritis;  histopathology;  hospital admission;  human;  human tissue;  kidney biopsy;  laboratory test;  preschool child;  priority journal;  remission;  treatment duration;  treatment failure;  treatment outcome;  treatment response;  urinalysis",
    abstract = "Henoch-Schönlein purpura glomerulonephritis (HSP-GN) is a common form of systemic small vessel vasculitis in children. Although prognosis is usually favourable, the disease is occasionally associated with a risk of renal insufficiency. Various immunosuppressive agents have been used in patients with severe HSP-GN, but none have shown convincing favourable effects. We report a case of biopsy-proven HSP-related GN in a 4-year-old girl that responded remarkably well to cyclosporine A (CsA), following failure to respond to other immunosuppressive agents. At 8 months post-CsA treatment, repeat renal biopsy findings were consistent with histological improvement. We conclude that CsA treatment not only exerts beneficial effects on resistant HSP-related GN but may also arrest progression of the disease. © The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved."
}