@article{3112737,
    title = "Sister Mary Joseph's nodule: Three case reports",
    author = "Larentzakis, A. and Theodorou, D. and Fili, K. and Manataki, A. and Bizimi, V. and Tibishrani, M. and Katsaragakis, S.",
    journal = "Cases Journal",
    year = "2008",
    volume = "1",
    number = "1",
    publisher = "BioMed Central Ltd.",
    issn = "1757-1626",
    doi = "10.1186/1757-1626-1-182",
    keywords = "antineoplastic agent, abdominal tenderness;  abdominal wall;  adenocarcinoma;  adipose tissue;  adult;  advanced cancer;  anemia;  Article;  cancer chemotherapy;  cancer fatigue;  case report;  clinical examination;  colon adenocarcinoma;  colon biopsy;  colonoscopy;  computer assisted tomography;  constipation;  cystectomy;  diarrhea;  dysuria;  echography;  female;  gallbladder adenocarcinoma;  gallbladder adenocarcinoma;  gallbladder cancer;  hematuria;  human;  hydronephrosis;  hypertension;  lower abdominal pain;  male;  middle aged;  pelvis lymph node;  percutaneous biopsy;  rectus abdominis muscle;  Sister Mary Joseph nodule;  transitional cell carcinoma;  umbilicus;  weight reduction",
    abstract = "Background: An umbilical metastatic lesion is called 'Sister Mary Joseph's nodule'. It is an uncommon clinical or radiographic finding, and it is rare as the first sign of a malignant disease.
Case presentation: We report three cases of Sister Mary Joseph's nodule. In the three cases presented, the primary tumor was an adenocarcinona of the sigmoid colon, a carcinoma of the bladder, and an adenocarcinoma of the gallbladder, respectively.
Conclusion: The differential diagnosis of an umbilical lesion should always include metastatic disease apart from benign lesions and primary neoplasms. © 2008 Larentzakis et al; licensee BioMed Central Ltd."
}