@article{3113199,
    title = "Genetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers",
    author = "Vineis, P. and Veglia, F. and Garte, S. and Malaveille, C. and Matullo, G. and Dunning, A. and Peluso, M. and Airoldi, L. and Overvad, K. and Raaschou-Nielsen, O. and Clavel-Chapelon, F. and Linseisen, J.P. and Kaaks, R. and Boeing, H. and Trichopoulou, A. and Palli, D. and Crosignani, P. and Tumino, R. and Panico, S. and Bueno-De-Mesquita, H.B. and Peeters, P.H. and Lund, E. and Gonzalez, C.A. and Martinez, C. and Dorronsoro, M. and Barricarte, A. and Navarro, C. and Quiros, J.R. and Berglund, G. and Jarvholm, B. and Day, N.E. and Key, T.J. and Saracci, R. and Riboli, E. and Autrup, H.",
    journal = "Annals of Oncology",
    year = "2007",
    volume = "18",
    number = "7",
    pages = "1230-1242",
    publisher = "Oxford University Press",
    issn = "0923-7534, 1569-8041",
    doi = "10.1093/annonc/mdm109",
    keywords = "5,10 methylenetetrahydrofolate reductase (FADH2);  cytochrome P450 1A1;  cytochrome P450 1B1;  glutathione transferase M1;  manganese superoxide dismutase;  reduced nicotinamide adenine dinucleotide phosphate dehydrogenase;  tobacco smoke, adult;  aged;  air pollution;  allele;  article;  bladder cancer;  cancer risk;  case control study;  cohort analysis;  confidence interval;  controlled study;  environmental factor;  female;  gene deletion;  gene interaction;  genetic association;  genetic susceptibility;  genetic variability;  heterozygote;  homozygote;  human;  lung cancer;  major clinical study;  male;  metabolism;  myeloid leukemia;  onset age;  oxidative stress;  priority journal;  risk assessment;  single nucleotide polymorphism;  smoking;  smoking habit;  statistical significance",
    abstract = "Background: We chose a set of candidate single nucleotide polymorphisms (SNPs) to investigate gene-environment interactions in three types of cancer that have been related to air pollution (lung, bladder and myeloid leukemia). Patients and methods: The study has been conducted as a nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort (409 cancer cases and 757 matched controls). We included never and ex-smokers. SNPs were in genes involved in oxidative stress, phase I metabolizing genes, phase II metabolizing genes and methylenetetrahydrofolate reductase (MTHFR). Results: The most notable findings are: GSTM1 deletion and bladder cancer risk [odds ratio (OR) = 1.60; 95% confidence interval 1.00-2.56]; CYP1A1 and leukemia (2.22, 1.33-3.70; heterozygotes); CYP1B1 and leukemia (0.47, 0.27-0.84; homozygotes); MnSOD and leukemia (1.91, 1.08-3.38; homozygotes) and NQO1 and lung cancer (8.03, 1.73-37.3; homozygotes). Other statistically significant associations were found in subgroups defined by smoking habits (never or ex-smokers), environmental tobacco smoke or gender, with no obvious pattern. When gene variants were organized according to the three main pathways, the emerging picture was of a strong involvement of combined phase I enzymes in leukemia, with an OR of 5 (1.63-15.4) for those having three or more variant alleles. The association was considerably stronger for leukemias arising before the age of 55. © 2007 European Society for Medical Oncology."
}