@article{3114219,
    title = "The effect of vitamin K supplementation on biochemical markers of bone
formation in children and adolescents with cystic fibrosis",
    author = "Nicolaidou, Polyxeni and Stavrinadis, Ilias and Loukou, Ioanna and and Papadopoulou, Anna and Georgouli, Helen and Douros, Konstantinos and and Priftis, Kostas N. and Gourgiotis, Dimitrios and Matsinos, Yiannis G. and and Doudounakis, Stavros",
    journal = "European Journal of Pediatrics",
    year = "2006",
    volume = "165",
    number = "8",
    pages = "540-545",
    publisher = "Springer-Verlag",
    issn = "0340-6199, 1432-1076",
    doi = "10.1007/s00431-006-0132-1",
    keywords = "cystic fibrosis; osteopenia; osteoporosis; vitamin D; vitamin K",
    abstract = "Introductions: Impaired vitamin K status in cystic fibrosis (CF) has
been considered as a newly emerged pathogenetic factor for reduced bone
mineral density (BMD). Objectives: Our aim was to evaluate the
effectiveness of vitamin K supplementation in managing bone formation
abnormalities in children and adolescents with CF. materials and
methods: The statuses of vitamins K and D in relation to biochemical
markers of bone metabolism and BMD were examined in 20 CF children
receiving vitamin D supplements but not vitamin K supplements.
Laboratory tests were carried out at the beginning of the study period
and after 1 year of vitamin K supplementation (10 mg single oral
dose/week) and the results were compared; the results were also compared
with those of 25 healthy controls. Results and discussions: Ten of the
CF patients had BMD z-score <= 2.5 (n=5) or between -1 and -2.5 (n=5).
Biochemical tests on patients before vitamin K supplementation revealed
that the levels of osteoblastic activity markers, namely, bone alkaline
phosphatase (BAP), serum osteocalcin (Gla-OC), serum carboxy-terminal
propeptide of type I procollagen (PICP) and serum amino-terminal
propeptide of type I procollagen (PINP), were significantly reduced
compared with those of the controls. These patients had also lower
25-hydroxy-vitamin D (25(OH)D) and vitamin K serum levels, higher
undercaboxylated osteocalcin (Glu-OC) and parathormone (PTH) levels and
a higher calcium to creatinine ratio (Ca/Cr) than the controls. Vitamin
K intake was associated with an increase in Gla-OC, PINP, PICP levels
and a decrease in Glu-OC levels. PTH levels were lower after vitamin K
supplementation without any difference in BMD z-scores. Conclusions: Our
data indicate that vitamin K supplementation may have a beneficial role
in bone health in CF children."
}