@article{3114768,
    title = "Monocytes as a site of production of soluble triggering receptor
expressed on myeloid cells-1 (sTREM-1) in the septic host",
    author = "Plachouras, Diamantis and Routsi, Christina and Giamarellos-Bourboulis, and Evangelos J. and Spyridaki, Ekaterini and Andrianakis, Ilias and and Metzelopoulos, Spyridon and Tsaganos, Thomas and Floros, Ioannis and and Douzinas, Emmanuel E. and Armaganidis, Apostolos and Roussos, Charis and and Giamarellou, Helen",
    journal = "Scandinavian Journal of Infectious Diseases",
    year = "2006",
    volume = "38",
    number = "10",
    pages = "909-915",
    publisher = "Informa Healthcare",
    issn = "0036-5548, 1651-1980",
    doi = "10.1080/00365540600786523",
    abstract = "The role of blood monocytes in the secretion of soluble triggering
receptor expressed on myeloiod cells (sTREM-1) was studied in 90
patients with septic syndrome due to ventilator-associated pneumonia.
Blood monocytes were isolated on 7 consecutive d after initiation of
symptoms. Monocytes were incubated in the absence or presence of LPS and
concentrations of sTREM-1 and TNF alpha in cell supernatants and serum
were estimated by an enzyme-immunoassay. sTREM-1 and TNF alpha were
consistently present at detectable levels in the cell supernatants. LPS
induced increased levels of TNFa but not of sTREM-1. Supernatants
recovered from monocytes on d 1 showed levels of sTREM-1 higher than
those recovered on any of the following 6 d (p < 0.05); these levels
were higher in non-survivors than in survivors. Supernatants recovered
from monocytes on d 1 of patients with severe sepsis had elevated
concentrations of sTREM-1 compared to patients with septic shock and
similar to patients with sepsis. A negative correlation was found
between levels of sTREM-1 in the cell supernatants and the percentage of
apoptotic monocytes. In essence, the above results suggest that
monocytes contribute to the production of sTREM-1 in the event of septic
syndrome."
}