@article{3114934,
    title = "Body mass index, waist circumference and waist-hip ratio and serum
levels of IGF-I and IGFBP-3 in European women",
    author = "Gram, I. T. and Norat, T. and Rinaldi, S. and Dossus, L. and Lukanova, and A. and Tehard, B. and Clavel-Chapelon, F. and van Gils, C. H. and van and Noord, P. A. H. and Peeters, P. H. M. and Bueno-de-Mesquita, H. B. and and Nagel, G. and Linseisen, J. and Lahmann, P. H. and Boeing, H. and Palli, and D. and Sacerdote, C. and Panico, S. and Tumino, R. and Sieri, S. and and Dorronsoro, M. and Quiros, J. R. and Navarro, C. A. and Barricarte, A. and and Tormo, M-J and Gonzalez, C. A. and Overvad, K. and Johnsen, S. and Paaske and Olsen, A. and Tjonneland, A. and Travis, R. and Allen, N. and and Bingham, S. and Khaw, K-T and Stattin, P. and Trichopoulou, A. and and Kalapothaki, V. and Psaltopoulou, T. and Casagrande, C. and Riboli, E. and and Kaaks, R.",
    journal = "International Journal of Obesity Supplements",
    year = "2006",
    volume = "30",
    number = "11",
    pages = "1623-1631",
    publisher = "Nature Publishing Group",
    issn = "2046-2166, 2046-2174",
    doi = "10.1038/sj.ijo.0803324",
    keywords = "IGF-I; IGFBP-3; body mass index; waist-hip ratio; women",
    abstract = "Objective: To examine the relationship between body mass index (BMI) and
waist-hip ratio (WHR) with serum levels of insulin-like growth factor-I
(IGF-I), and its binding protein (IGFBP)-3.
Design: Cross-sectional study on 2139 women participating in a
case-control study on breast cancer and endogenous hormones. Data on
lifestyle and reproductive factors were collected by means of
questionnaires. Body height, weight, waist and hip circumferences were
measured. Serum levels of IGF-I and insulin-like binding protein
(IGFBP)-3 were measured by enzyme-linked immunosorbent assays. Adjusted
mean levels of IGF-I and IGFBP-3 across quintiles of BMI, waist
circumference, and WHR were calculated by linear regression. Results
were adjusted for potential confounders associated with IGF-I and
IGFBP-3.
Results: Adjusted mean serum IGF-I values were lower in women with BMI <
22.5 kg/m(2) or BMI > 29.2 kg/m(2) compared to women with BMI within
this range (P-heterogeneity < 0.0001, P-trend = 0.35). Insulin-like
growth factor-I was not related to WHR after adjustment for BMI.
IGF-binding protein-3 was linearly positively related to waist and WHR
after mutual adjustment. The molar ratio IGF-I/IGFBP-3 had a non-linear
relation with BMI and a linear inverse relationship with WHR (P-trend =
0.005).
Conclusions: Our data confirm the nonlinear relationship of circulating
IGF-I to total adiposity in women. Serum IGFBP-3 was positively related
to central adiposity. These suggest that bioavailable IGF-I levels could
be lower in obese compared to non-obese women and inversely related to
central adiposity."
}