@article{3116024,
    title = "Parecoxib vs. lornoxicam in the treatment of postoperative pain after
laparoscopic cholecystectomy: a prospective randomized
placebo-controlled trial",
    author = "Papadima, A. and Lagoudianakis, E. E. and Antonakis, P. T. and Pattas, and M. and Kremastinou, F. and Katergiannakis, V. and Manouras, A. and and Georgiou, L.",
    journal = "European Journal of Anaesthesiology",
    year = "2007",
    volume = "24",
    number = "2",
    pages = "154-158",
    publisher = "Lippincott, Williams & Wilkins",
    issn = "0265-0215, 1365-2346",
    doi = "10.1017/S0265021506001293",
    keywords = "surgery, abdominal; lornoxicam; parecoxib; pain acute and postoperative;
cholecystectomy laparoscopic",
    abstract = "Background and objective: Non-steroidal anti-inflammatory drugs are
considered as an effective treatment of postoperative pain after
laparoscopic cholecystectomy. COX-2 inhibitors are newer drugs having
less adverse effects. Data supporting their efficacy postoperatively in
comparison to older non-steroidal anti-inflammatory drugs are scarce.
Our study is a prospective, randomized, double-blinded,
placebo-controlled trial comparing the efficacy of lornoxicam vs.
parecoxib for the management of pain after laparoscopic cholecystectomy.
Materials and methods: We enrolled 76 patients, ASA I and 11, scheduled
for elective laparoscopic cholecystectomy. The patients were randomized
to receive before induction parecoxib 40 mg i.v., lornoxicam 8 mg i.v.
or placebo. Pain at rest and on movement was assessed using a visual
analogue scale at 0, 6, 12 h postoperatively. Total meperidine
consumption and adverse effects were also recorded. Results: At 12 h,
visual analogue scale scores at rest and on movement were significantly
lower with parecoxib and lornoxicam compared with control (P = 0.047).
The percentage of patients needing meperidine and the average dose of
meperidine administered was significantly lower with parecoxib and
lornoxicam compared with control (P < 0.001 and P = 0.018). There was no
difference between parecoxib and lornoxicam. One patient receiving
lornoxicam vomited. Conclusions: Parecoxib 40 mg i.v. and lornoxicam 8
mg IN. were equianalgesic and both were more efficacious than placebo
for the management of pain after laparoscopic cholecystectomy."
}