@article{3116031,
    title = "EPIC-Heart: The cardiovascular component of a prospective study of
nutritional, lifestyle and biological factors in 520,000 middle-aged
participants from 10 European countries",
    author = "Danesh, John and Saracci, Rodolfo and Berglund, Goran and Feskens, Edith and and Overvad, Kim and Panico, Salvatore and Thompson, Simon and Fournier, and Agnes and Clavel-Chapelon, Francoise and Canonico, Marianne and Kaaks, and Rudolf and Linseisen, Jakob and Boeing, Heiner and Pischon, Tobias and and Weikert, Cornelia and Olsen, Anja and Tjonneland, Anne and Johnsen, and Soren Paaske and Jensen, Majken Karoline and Quiros, Jose R. and and Gonzalez Svatetz, Carlos Alberto and Sanchez Perez, Maria-Jose and and Larranaga, Nerea and Navarro Sanchez, Carmen and Moreno Iribas, and Concepcion and Bingham, Sheila and Khaw, Kay-Tee and Wareham, Nick and and Key, Timothy and Roddam, Andrew and Trichopoulou, Antonia and Benetou, and Vassiliki and Trichopoulos, Dimitrios and Masala, Giovanna and Sieri, and Sabina and Tumino, Rosario and Sacerdote, Carlotta and Mattiello, Amalia and and Verschuren, W. M. Monique and Bueno-de-Mesquita, H. Bas and Grobbee, and Diederick E. and van der Schouw, Yvonne T. and Melander, Olle and and Hallmans, Goran and Wennberg, Patrik and Lund, Eiliv and Kumle, Merethe and and Skeie, Guri and Ferrari, Pietro and Slimani, Nadia and Norat, Teresa and and Riboli, Elio",
    journal = "European Journal of Epidemiology",
    year = "2007",
    volume = "22",
    number = "2",
    pages = "129-141",
    publisher = "Springer-Verlag",
    issn = "0393-2990, 1573-7284",
    doi = "10.1007/s10654-006-9096-8",
    keywords = "diet; EPIC heart; prospective study; study protocol",
    abstract = "EPIC-Heart is the cardiovascular component of the European Prospective
Investigation into Cancer and Nutrition ( EPIC), a multi-centre
prospective cohort study investigating the relationship between
nutrition and major chronic disease outcomes. Its objective is to
advance understanding about the separate and combined influences of
lifestyle ( especially dietary), environmental, metabolic and genetic
factors in the development of cardiovascular diseases by making best
possible use of the unusually informative database and biological
samples in EPIC. Between 1992 and 2000, 519,978 participants ( 366,521
women and 153,457 men, mostly aged 35 - 70 years) in 23 centres in 10
European countries commenced follow-up for causespecific mortality,
cancer incidence and major cardiovascular morbidity. Dietary information
was collected with quantitative questionnaires or semi-quantitative food
frequency questionnaires, including a 24-h dietary recall sub-study to
help calibrate the dietary measurements. Information was collected on
physical activity, tobacco smoking, alcohol consumption, occupational
history, socio-economic status, and history of previous illnesses.
Anthropometric measurements and blood pressure recordings were made in
the majority of participants. Blood samples were taken from 385,747
individuals, from which plasma, serum, red cells, and buffy coat
fractions were separated and aliquoted for long-term storage. By 2004,
an estimated 10,000 incident fatal and non-fatal coronary and stroke
events had been recorded. The first cycle of EPIC-Heart analyses will
assess associations of coronary mortality with several prominent dietary
hypotheses and with established cardiovascular risk factors. Subsequent
analyses will extend this approach to non-fatal cardiovascular outcomes
and to further dietary, biochemical and genetic factors."
}