@article{3116341,
    title = "High-dose ascorbic acid decreases cholesterolernic factors of an
atherogenic diet in guinea pigs",
    author = "Filis, Konstantinos and Anastassopoulou, Aikaterini and Sigala, Fragiska and and Theodorou, Dimitrios and Manouras, Andreas and Leandros, Emanouel and and Sigalas, Panagiotis and Hepp, Wolfgang and Bramis, John",
    journal = "International journal for vitamin and nutrition research",
    year = "2007",
    volume = "77",
    number = "2",
    pages = "125-129",
    publisher = "Verlag Hans Huber",
    issn = "0300-9831",
    doi = "10.1024/0300-9831.77.2.125",
    keywords = "hyperlipidemia; ascorbic acid; atherosclerosis; cholesterol; diet",
    abstract = "Background: The study evaluates the effect of a high supplemental dose
of ascorbic acid (AA) on plasma concentrations of total cholesterol
(TC), triglycerides (TG), total lipids (TL), and lipoprotein fractions
high-density, very-low-density-, and low-density lipoprotein (HDL, VLDL,
LDL) in guinea pigs fed with atherogenic, diet.
Methods: Group I consisted of 5 normally fed guinea pigs plus a low dose
of AA (1 mg/100 g/day), group II consisted of 7 guinea pigs fed with
food enriched with 2% cholesterol plus a low dose of AA (1 mg/100
g/day), and group III consisted of 7 guinea pigs fed with food enriched
with 2% cholesterol plus a high dose of AA -(30 mg/100 g/day).
Cholesterolemic factors concentrations were determined, after nine
weeks.
Results: Concentrations of TC, TG, TL, LDL, and VLDL were increased in
group II compared to group I (p < 0.01 for all differences).
Supplementation with a high dose of AA resulted in decreased
concentrations of TC (p < 0.01), TG (p < 0.01), TL (p < 0.01), and LDL
(p < 0.01) in group III compared to group II. Additionally,
concentration of HDL was increased in group III compared to group II (p
< 0.01).
Conclusion: High-dose AA supplementation to an atherogenic diet
decreases concentrations of TC, TG, TL, and LDL and increases
concentration of HDL compared to low-dose AA."
}