@article{3116769,
    title = "The association between pre-hypertension status and oxidative stress
markers related to atherosclerotic disease: The ATTICA study",
    author = "Chrysohoou, Christina and Panagiotakos, Demosthenes B. and Pitsavos, and Christos and Skoumas, John and Economou, Manolis and Papadimitriou, and Lambros and Stefanadis, Christodoulos",
    journal = "Atherosclerosis",
    year = "2007",
    volume = "192",
    number = "1",
    pages = "169-176",
    publisher = "Elsevier Ireland Ltd",
    issn = "0021-9150",
    doi = "10.1016/j.atherosclerosis.2006.04.030",
    keywords = "pre-hypertension; oxidation; atherosclerosis",
    abstract = "Background: We sought to evaluate the association between
pre-hypertension status and oxidative stress markers (total antioxidant
capacity (TAC) and oxidized low density lipoprotein (LDL)), in a random
sample of cardiovascular disease-free adults.
Methods: The ATTICA study is a cross-sectional population-based survey
that conducted in Attica region during 2001-2002. Based on a multistage
and stratified random sampling, 1514 men and 1528 women (18-89 years
old) were enrolled. The survey included a detailed interview; blood
samples collected after 12 h of fasting and, among other clinical
measurements, status of blood pressure levels was evaluated.
Results: Six hundred and fifty-three men (43%) and 535 women (35%)
were defined as pre-hypertensives. Both systolic and diastolic blood
pressures were inversely correlated with TAC (p < 0.001) and positively
correlated to oxidized LDL (p < 0.001). Particularly, compared to
normotensive subjects, pre-hypertensives had 7% lower TAC levels (p <
0.001) and 15% higher oxidized LDL levels (p < 0.05), after correcting
for multiple comparisons and adjusting for age, body mass index, blood
lipids, glucose, food groups consumed and other potential confounders.
Conclusions: Studying a large sample of cardiovascular disease-free
adults, we revealed an association of pre-hypertension with oxidative
stress markers linking to atherosclerotic process. (c) 2006 Elsevier
Ireland Ltd. All rights reserved."
}