@article{3118752,
    title = "Different pregnancy outcomes according to the polycystic ovary syndrome diagnostic criteria: a systematic review and meta-analysis of 79 studies",
    author = "Chatzakis, C. and Tsakmaki, E. and Psomiadou, A. and Charitakis, N. and Eleftheriades, M. and Dinas, K. and Goulis, D. and Sotiriadis, A.",
    journal = "Fertility and Sterility",
    year = "2022",
    publisher = "HANLEY & BELFUS-ELSEVIER INC",
    issn = "0015-0282, 1556-5653",
    doi = "10.1016/j.fertnstert.2021.12.027",
    abstract = "Objective: To correlate the distinct diagnostic criteria of polycystic ovary syndrome (PCOS) with the development of maternal and neonatal complications. Design: Systematic review and meta-analysis. Setting: Not applicable. Patient(s): Pregnant women with PCOS. Intervention(s): Maternal and neonatal complications were compared among women with PCOS diagnosed with different criteria. Main Outcome Measure(s): The primary outcomes of gestational diabetes mellitus and preeclampsia (PE) were assessed for every diagnostic criterion. Result(s): Seventy-nine studies were included. Regarding gestational diabetes, the overall pooled prevalence was 14% (95% confidence interval [CI], 11%–18%; I2, 97%), reaching the highest level when polycystic ovarian morphology on ultrasound and 1 of the remaining 2 Rotterdam criteria (1/2 Rotterdam criteria) were used (18%; 95% CI, 13%–24%; I2, 20%) and the lowest when polycystic morphology on ultrasound and hyperandrogenism were used (3%; 95% CI, 0%–19%; I2, not applicable). Regarding PE, the overall pooled prevalence was 5% (95% CI, 4%–7%; I2, 82%). The highest PE prevalence was reported when the National Institutes of Health criteria were used (14%; 95% CI, 5%–33%; I2, 90%) and the lowest when menstrual irregularities and 1 of the 2 Rotterdam criteria were used (2%; 95% CI, 1%–3%; I2, not applicable). Conclusion(s): The prevalence of gestational diabetes mellitus in pregnant women with PCOS does not differ according to the criteria used; however, women diagnosed with PCOS per the National Institutes of Health criteria are at higher risk of PE. © 2021 American Society for Reproductive Medicine"
}