@article{3120386,
    title = "Perinatal outcome of appropriate-weight fetuses with decelerating growth",
    author = "Chatzakis, C. and Papaioannou, G.-K. and Eleftheriades, M. and Makrydimas, G. and Dinas, K. and Sotiriadis, A.",
    journal = "Journal of Maternal-Fetal and Neonatal Medicine",
    year = "2021",
    volume = "34",
    number = "20",
    pages = "3362-3369",
    publisher = "Taylor and Francis Ltd.",
    issn = "1476-7058, 1476-4954",
    doi = "10.1080/14767058.2019.1684470",
    keywords = "adult;  area under the curve;  Article;  birth weight;  cesarean section;  cohort analysis;  crown rump length;  female;  fetus growth;  fetus weight;  gestational age;  human;  information processing;  intrauterine growth retardation;  major clinical study;  menstrual cycle;  middle cerebral artery;  newborn intensive care;  outcome assessment;  people by smoking status;  perinatal care;  perinatal death;  second trimester pregnancy;  third trimester pregnancy;  ultrasound;  cesarean section;  fetus;  fetus echography;  intrauterine growth retardation;  newborn;  pregnancy;  pregnancy outcome;  small for date infant, Cesarean Section;  Female;  Fetal Growth Retardation;  Fetal Weight;  Fetus;  Gestational Age;  Humans;  Infant, Newborn;  Infant, Small for Gestational Age;  Pregnancy;  Pregnancy Outcome;  Ultrasonography, Prenatal",
    abstract = "Introduction: To assess the perinatal outcome of fetuses dropping by ≥50 estimated fetal weight (EFW) centiles between the second and third trimester. Methods: Singleton pregnancies progressing after 32 + 0 weeks, who had their second- and third-trimester scans at our institutions were enrolled in the study. The perinatal outcome of AGA fetuses crossing more than 50 centiles was compared to that of fetuses with FGR, small for gestational age (SGA) and nondecelerating appropriate for gestational age (AGA). The primary perinatal outcomes were perinatal death, neonatal intensive care (NICU) admission and emergency cesarean section (CS). The rates of these outcomes were compared between the four groups and regression analysis was performed to account for maternal and fetal confounders. Results: Our analysis included 4394 cases. Compared to nondecelerating SGA, fetuses crossing ≥50 centiles had higher rates of NICU admission (odds ratio [OR] 1.8, 95% confidence interval [CI] CI 1.1–3.1) and perinatal death (OR 3.8, 95%CI 1.3–11.4). Regression analysis showed that significant independent predictors for NICU admission included maternal age, gestational age at birth and FGR (area under the curve [AUC] 0.851), whereas significant predictors for perinatal death included maternal age, gestational age at birth, decelerating growth ≥50 centiles, conception through ART and third-trimester CPR centile (AUC 0.801). Conclusion: AGA fetuses that cross >50 EFW centiles between the second and third trimester are at increased risk of adverse perinatal outcome and it seems advisable that they are followed up as typical FGR cases. © 2019 Informa UK Limited, trading as Taylor & Francis Group."
}