@article{3120388,
    title = "Comparison of Chemokine CXCL-1 and Interleukin-6 Concentrations in the Subretinal Fluid and Vitreous in Rhegmatogenous Retinal Detachment",
    author = "Symeonidis, C. and Rotsos, T. and Matsou, A. and Dermenoudi, M. and Georgalas, I. and Tsinopoulos, I. and Makri, O. and Souliou, E. and Dimitrakos, S.A.",
    journal = "Ocular Immunology and Inflammation",
    year = "2021",
    volume = "29",
    number = "2",
    pages = "355-361",
    publisher = "Taylor and Francis Ltd.",
    issn = "0927-3948, 1744-5078",
    doi = "10.1080/09273948.2019.1672197",
    keywords = "CXCL1 chemokine;  interleukin 6;  biological marker;  CXCL1 chemokine;  CXCL1 protein, human;  interleukin 6, adult;  aged;  aphakia;  Article;  controlled study;  cytokine production;  enzyme linked immunosorbent assay;  female;  human;  human tissue;  major clinical study;  male;  pars plana vitrectomy;  protein expression;  retina detachment;  sclera buckling procedure;  subretinal fluid;  vitreoretinopathy;  vitreous body;  comparative study;  complication;  metabolism;  middle aged;  retina detachment;  subretinal fluid;  very elderly;  vitreoretinopathy;  vitreous body;  young adult, Adult;  Aged;  Aged, 80 and over;  Biomarkers;  Chemokine CXCL1;  Enzyme-Linked Immunosorbent Assay;  Female;  Humans;  Interleukin-6;  Male;  Middle Aged;  Retinal Detachment;  Subretinal Fluid;  Vitreoretinopathy, Proliferative;  Vitreous Body;  Young Adult",
    abstract = "Purpose: Comparison of IL-6 and CXCL-1 concentrations and CXCL-1/IL-6 ratio correlations with clinical parameters (RRD extent, duration, and proliferative vitreoretinopathy–PVR-grade) between subretinal fluid (SRF) and vitreous during rhegmatogenous retinal detachment (RRD) complicated with PVR. Methods: A total of 71 eyes of 71 patients with primary RRD possibly complicated with PVR were included; 36 eyes treated with scleral buckling and 35 eyes with pars-plana vitrectomy. Enzyme-Linked Immuno-sorbent Assay was employed for CXCL-1/IL-6 measurement (ng/ml). Results: Correlation analysis between mean CXCL-1/IL-6 ratio and clinical parameters revealed non-significant results. CXCL-1/IL-6 ratio was significantly elevated in phakic eye vitreous. Optimum circumstances for elevated chemokine levels during RRD were considerable extent (2-3-quadrant) and duration (29-60-day) complicated with PVR C. Conclusions: SRF appears to be characterized by greater chemokine concentrations while vitreous retains several structural characteristics that may assist in investigating inflammation and improving understanding of underlying pathophysiological mechanisms during RRD complicated with PVR. © 2019 Taylor & Francis Group, LLC."
}