@article{3121277,
    title = "Salivary inflammatory markers in tension type headache and migraine: the SalHead cohort study",
    author = "Bougea, A. and Spantideas, N. and Galanis, P. and Katsika, P. and Boufidou, F. and Voskou, P. and Vamvakaris, I. and Anagnostou, E. and Nikolaou, X. and Kararizou, E.",
    journal = "Neurological Sciences",
    year = "2020",
    volume = "41",
    number = "4",
    pages = "877-884",
    publisher = "Springer-Verlag",
    issn = "1590-1874, 1590-3478",
    doi = "10.1007/s10072-019-04151-4",
    keywords = "C reactive protein;  interleukin 1beta;  interleukin 6;  C reactive protein;  IL1B protein, human;  IL6 protein, human;  interleukin 1beta;  interleukin 6, adult;  anxiety;  Article;  Beck Depression Inventory;  comorbidity;  controlled study;  depression;  enzyme linked immunosorbent assay;  female;  Hamilton Anxiety Scale;  human;  inflammation;  longitudinal study;  major clinical study;  male;  migraine;  prospective study;  saliva level;  tension headache;  clinical trial;  depression;  immunology;  inflammation;  metabolism;  middle aged;  migraine;  register;  saliva;  tension headache;  time factor, Adult;  Anxiety;  C-Reactive Protein;  Comorbidity;  Depression;  Female;  Humans;  Inflammation;  Interleukin-1beta;  Interleukin-6;  Longitudinal Studies;  Male;  Middle Aged;  Migraine Disorders;  Registries;  Saliva;  Tension-Type Headache;  Time Factors",
    abstract = "Objective: To investigate the possible association between salivary CRP, IL-1β, and IL-6 levels, depression/anxiety and migraine, and tension type headache (TTH) in saliva of these patients. Method: A longitudinal prospective study was conducted on 30 migraineurs, 30 TTH patients, and 30 age-matched healthy controls. Anxiety and depression were measured by using the Hamilton Anxiety Rating Scale (HAM-A), and the Beck Depression Inventory (BDI). Salivary IL-6, IL-1β, and CRP were collected in distinct time points as A: headache-free period, B: during headache, C: 1 day after headache attack, and measured by using ELISA kits. Results: No significant differences were found in time variation of CRP, IL-1β, and IL-6 levels between migraine and TTH (p > 0.05). IL1-β had the highest discriminative value (area under the curve = 0.924, p value < 0.001), and then CRP (area under the curve = 0.763, p value < 0.001) and IL-6 (area under the curve = 0.537, p value = 0.58). CRP and IL-6 were negatively correlated with HAM-A and BDI scores. Conclusion: IL1-β had the highest discriminative value between headache patients and controls compared with CRP and IL-6. CRP and IL-6 were correlated with lower symptom scores of anxiety and depression prior or immediately after the headache period in patients groups. © 2019, Fondazione Società Italiana di Neurologia."
}