@article{3121285,
    title = "Paraoxonase-1 and Symptomatic Status in Carotid Artery Disease",
    author = "Lioudaki, S. and Verikokos, C. and Kouraklis, G. and Kontopodis, N. and Markakis, G. and Ioannou, C. and Daskalopoulou, A. and Perrea, D. and Klonaris, C.",
    journal = "Annals of Vascular Surgery",
    year = "2020",
    volume = "64",
    pages = "355-360",
    publisher = "HANLEY & BELFUS-ELSEVIER INC",
    issn = "0890-5096",
    doi = "10.1016/j.avsg.2019.07.020",
    keywords = "aryldialkylphosphatase 1;  glucose;  high density lipoprotein cholesterol;  low density lipoprotein cholesterol;  triacylglycerol;  aryldialkylphosphatase;  biological marker;  lipid;  PON1 protein, human, aged;  Article;  carotid atherosclerosis;  carotid endarterectomy;  cholesterol blood level;  clinical feature;  computed tomographic angiography;  diagnostic accuracy;  digital subtraction angiography;  enzyme linked immunosorbent assay;  female;  Greece;  human;  major clinical study;  male;  neuroimaging;  priority journal;  asymptomatic disease;  blood;  carotid artery obstruction;  comparative study;  complication;  cross-sectional study;  down regulation;  glucose blood level;  middle aged, Aged;  Aryldialkylphosphatase;  Asymptomatic Diseases;  Biomarkers;  Blood Glucose;  Carotid Stenosis;  Cross-Sectional Studies;  Down-Regulation;  Endarterectomy, Carotid;  Female;  Humans;  Lipids;  Male;  Middle Aged",
    abstract = "Background: Paraoxonase-1 (PON-1) is a high-density lipoprotein (HDL)-associated hydrolase that appears to have a protective action against atherosclerosis. The aim of our study is to identify whether PON-1 levels may be associated with the manifestation of symptoms in patients with carotid artery stenosis. Methods: We studied all patients who underwent carotid endarterectomy in the Vascular Surgery Department of Laikon Hospital, Athens, Greece, from July 2012 to July 2014. Medical history was recorded and PON-1 glucose, total cholesterol, HDL cholesterol, low-density lipoprotein cholesterol, and triglycerides levels were measured. Variables were compared between symptomatic and asymptomatic patients. A receiver operating characteristic (ROC) curve was constructed to evaluate the accuracy of PON-1 to predict symptoms. Results: A total of 74 patients were included, 41 were asymptomatic and the mean age was 68.5 years. The 2 groups appear to differ significantly with regards to the PON-1 levels, with the symptomatic group showing lower levels (5.3 ± 1.19 vs. 4.6 ± 1.36 ng/mL; P = 0.025). ROC analysis demonstrated an area under the curve of 0.654 (P = 0.023). Conclusions: Reduced PON-1 levels showed a significant association with symptomatic status, which was independent of other traditional cardiovascular factors. Further studies are required to prospectively assess the role of PON-1 in predicting cerebrovascular events in patients with carotid artery disease. © 2019 Elsevier Inc."
}