@article{3121349,
    title = "The different faces of mycosis fungoides: results of a single-center study",
    author = "Sidiropoulou, P. and Nikolaou, V. and Marinos, L. and Voudouri, D. and Komini, E. and Economidi, A. and Rigopoulos, D. and Stratigos, A.",
    journal = "International Journal of Dermatology",
    year = "2020",
    volume = "59",
    number = "3",
    pages = "314-320",
    publisher = "Wiley-Blackwell Publishing Ltd",
    issn = "0011-9059, 1365-4632",
    doi = "10.1111/ijd.14735",
    keywords = "adult;  Article;  cancer growth;  cancer staging;  classical mycosis fungoides;  cohort analysis;  controlled study;  demography;  disease duration;  female;  folliculotropic mycosis fungoides;  follow up;  human;  human tissue;  immunohistochemistry;  incidence;  major clinical study;  male;  mycosis fungoides;  poikilodermic mycosis fungoides;  prevalence;  psoriasiform mycosis fungoides;  retrospective study;  skin biopsy;  adolescent;  aged;  biopsy;  child;  Greece;  middle aged;  mycosis fungoides;  pathology;  preschool child;  register;  skin;  skin tumor;  young adult, Adolescent;  Adult;  Aged;  Biopsy;  Child;  Child, Preschool;  Female;  Greece;  Humans;  Immunohistochemistry;  Male;  Middle Aged;  Mycosis Fungoides;  Prevalence;  Registries;  Retrospective Studies;  Skin;  Skin Neoplasms;  Young Adult",
    abstract = "Background: Mycosis fungoides (MF) accounts for the majority of cutaneous lymphomas. Apart from the predominant Alibert-Bazin type, several clinicopathological variants of diverse prevalence and biological behavior have been described. Data on clinical and epidemiological aspects of MF clinical subtypes are still weak. Aim: To outline the clinical and epidemiological profile of the different MF types in a large volume of Greek patients. Methods: Retrospective analysis of 688 MF cases treated in our lymphoma clinic. Epidemiological, clinical, pathological, and immunohistochemical data were retrieved. Results: Six-hundred and thirty-six patients (416 males, 220 females) were included. The mean age at diagnosis was 60.2 years; the mean duration of disease prior to diagnosis was 63.2 months. Early-stage MF (I-IIA) involved 475 cases (74.7%). The prevalent type was classical MF (68.5%), followed by folliculotropic (17%), poikilodermic (5.5%), and psoriasiform (4.7%) MF. Atypical MF lesions as the sole manifestation of folliculotropic mycosis fungoides (FMF) – alopecia areata-like lesions (n = 10), keratosis pilaris-like lesions (n = 9) or acneiform rash (n = 4) – were also observed. Both poikilodermic and folliculotropic subtypes mainly involved younger patients. A significant diagnostic latency concerning poikilodermic and psoriasiform MF cases was recorded. Only 23 (3.3%) cases were of juvenile onset, with classical and poikilodermic MF equally affecting this age group, closely followed by FMF. Conclusions: Our study presents the whole clinical-epidemiological spectrum of MF in a large Greek cohort. The high prevalence of atypical MF manifestations characterized by early onset and indolent clinical course stood out among our FMF sample. © 2019 The International Society of Dermatology"
}