@article{3122359,
    title = "Nocturnal oximetry in children with obstructive lung disease or sleep-disordered breathing",
    author = "Katsouli, G. and Polytarchou, A. and Tsaoussoglou, M. and Loukou, I. and Chrousos, G. and Kaditis, A.G.",
    journal = "Pediatric Pulmonology",
    year = "2019",
    volume = "54",
    number = "5",
    pages = "551-556",
    publisher = "John Wiley and Sons Inc",
    issn = "8755-6863, 1099-0496",
    doi = "10.1002/ppul.24259",
    keywords = "oxygen, adenotonsillar hypertrophy;  age distribution;  Article;  blood oxygen tension;  bronchiolitis obliterans;  child;  chronic obstructive lung disease;  clinical article;  comparative study;  controlled study;  cystic fibrosis;  disease association;  female;  human;  male;  nocturnal oximetry;  oximetry;  oxygen desaturation;  priority journal;  retrospective study;  sleep disordered breathing;  snoring;  adenoid;  adolescent;  bronchiolitis obliterans;  cystic fibrosis;  differential diagnosis;  hypertrophy;  infant;  metabolism;  oximetry;  palatine tonsil;  preschool child;  procedures;  sleep disordered breathing;  snoring, Adenoids;  Adolescent;  Bronchiolitis Obliterans;  Child;  Child, Preschool;  Cystic Fibrosis;  Diagnosis, Differential;  Female;  Humans;  Hypertrophy;  Infant;  Male;  Oximetry;  Palatine Tonsil;  Sleep Apnea Syndromes;  Sleep Apnea, Obstructive;  Snoring",
    abstract = "Objectives: Although progress has been made in the standardized interpretation of nocturnal oximetry in children with obstructive sleep-disordered breathing (SDB), no evidence exists on oximetry abnormalities in other respiratory disorders. We aimed to compare obstructive lung disease (OLD) and SDB regarding nocturnal oximetry parameters. Methods: We analyzed oximetry recordings from children with (i) OLD (obliterative bronchiolitis; cystic fibrosis); (ii) snoring and adenotonsillar hypertrophy (SDB); and (iii) no respiratory disorder (controls). The three groups were compared regarding: (i) oxygen desaturation of hemoglobin index (SpO 2 drops ≥3%/h-ODI3) and (ii) basal SpO 2 (average SpO 2 between SpO 2 drops). The associations of oximetry parameters (natural logarithm) with study group were tested using linear regression including age as covariate. Results: Data of 16 subjects with OLD (median age: 7.3 years; Q25, Q75: 5.4, 12), 22 children with SDB (6.3 years; 4, 9) and 22 controls (6.8 years; 5.6, 10.3) were analyzed. Children with OLD or SDB had significantly lower basal SpO 2 than controls (91.9% [90.8, 93.4] vs 96.3% [96, 97.4] vs 97.6% [97.1, 97.9]; P < 0.01). No subjects in the SDB or control groups had basal SpO 2 < 95%. Children with SDB had significantly higher ODI3 than children with OLD or controls [8.4 episodes/h (6.2, 16.6) vs 4.4 episodes/h (3.6, 6.6) vs 2 episodes/h (1.3, 2.7); P < 0.01]. OLD had the greatest negative effect on basal SpO 2 (R 2 = 0.62; P < 0.001) and SDB the greatest positive effect on ODI3 (R 2 = 0.34; P < 0.001). Conclusion: OLD is associated mostly with reduced basal SpO 2 , whereas SDB is characterized by elevated ODI3. © 2019 Wiley Periodicals, Inc."
}