@article{3122881,
    title = "Platelet to lymphocyte and neutrophil to lymphocyte ratio as predictive indices of endometrial carcinoma: Findings from a retrospective series of patients and meta-analysis",
    author = "Pergialiotis, V. and Oikonomou, M. and Damaskou, V. and Kalantzis, D. and Chrelias, C. and Tsantes, A.E. and Panayiotides, I.",
    journal = "Journal of Gynecology Obstetrics and Human Reproduction",
    year = "2018",
    volume = "47",
    number = "10",
    pages = "511-516",
    publisher = "Elsevier Masson SAS",
    issn = "2468-7847",
    doi = "10.1016/j.jogoh.2018.08.016",
    keywords = "adult;  aged;  Article;  cancer diagnosis;  cancer grading;  cancer staging;  cancer surgery;  cancer survival;  case control study;  controlled study;  diagnostic accuracy;  diagnostic value;  dilatation and curettage;  disease free survival;  distant metastasis;  endometrial thickness;  endometrioid carcinoma;  endometrium carcinoma;  endometrium hyperplasia;  female;  human;  human cell;  human tissue;  lymph node metastasis;  lymph vessel metastasis;  lymphocyte monocyte ratio;  major clinical study;  meta analysis (topic);  neutrophil lymphocyte ratio;  overall survival;  platelet lymphocyte ratio;  predictive value;  retrospective study;  systematic review (topic);  vagina bleeding;  blood;  blood cell count;  endometrium tumor;  lymphocyte;  meta analysis;  middle aged;  neutrophil;  thrombocyte;  very elderly, biological marker, Aged;  Aged, 80 and over;  Biomarkers;  Blood Cell Count;  Blood Platelets;  Endometrial Neoplasms;  Female;  Humans;  Lymphocytes;  Middle Aged;  Neutrophils;  Retrospective Studies",
    abstract = "Background: The purpose of the present study is to present new data concerning the diagnostic efficacy of neutrophil to lymphocyte (NLR) and platelet to lymphocyte (PLR) ratios in detecting endometrial carcinoma and to summarize the existing knowledge by accumulating all the available data in the existing literature. Materials and methods: We retrospectively identified patients with evidence of endometrial pathology (vaginal bleeding or increased endometrial thickness) that undergone dilatation and curettage. For the meta-analysis we used the Medline, Scopus, Clinicaltrials.gov, EMBASE, Cochrane Central Register of Controlled Trials CENTRAL and Google Scholar databases to identify relevant articles in the field. Results: In our retrospective series we identified 106 women with endometrioid endometrial carcinoma and 72 controls. PLR and NLR values were comparable among the two groups (p >.05). Eleven studies were included in the present systematic review with a total of 4168 patients. The meta-analysis included 1013 patients. PLR values were not significantly different among the two groups. On the other hand, NLR was significantly raised among patients with endometrial carcinoma (MD 0.73, 95% CI 0.01, 1.45). Conclusion: The findings of our meta-analysis support that NLR values are significantly elevated in patients with endometrial cancer compared to controls. Moreover, there seem to be evidence to support that both PLR and NLR values increase in patients with advanced stage disease, including positive lymph nodes, lymphovascular space involvement and distant metastases. Future studies are needed in this field to reach firm conclusions and these should specifically target patients with advanced stage disease. © 2018 Elsevier Masson SAS"
}