@article{3122943,
    title = "Placental volume at 11 to 14 gestational weeks in pregnancies complicated with fetal growth restriction and preeclampsia",
    author = "Papastefanou, I. and Chrelias, C. and Siristatidis, C. and Kappou, D. and Eleftheriades, M. and Kassanos, D.",
    journal = "Prenatal Diagnosis",
    year = "2018",
    volume = "38",
    number = "12",
    pages = "928-935",
    publisher = "John Wiley and Sons Ltd",
    issn = "0197-3851, 1097-0223",
    doi = "10.1002/pd.5356",
    keywords = "chorionic gonadotropin beta subunit;  pregnancy associated plasma protein A, Article;  birth weight;  body weight;  controlled study;  crown rump length;  female;  fetus;  fetus echography;  fetus growth;  first trimester pregnancy;  gestational age;  human;  intrauterine growth retardation;  major clinical study;  maternal age;  maternal hypertension;  maternal smoking;  nuchal translucency measurement;  observational study;  parity;  placenta insufficiency;  placenta weight;  preeclampsia;  pregnancy complication;  premature labor;  priority journal;  prospective study;  pulsatility index;  uterine artery;  adult;  case control study;  diagnostic imaging;  intrauterine growth retardation;  organ size;  pathology;  placenta;  placenta disorder;  predictive value;  preeclampsia;  pregnancy;  register;  three dimensional imaging, Adult;  Case-Control Studies;  Female;  Fetal Growth Retardation;  Humans;  Imaging, Three-Dimensional;  Organ Size;  Placenta;  Placenta Diseases;  Placental Insufficiency;  Pre-Eclampsia;  Predictive Value of Tests;  Pregnancy;  Pregnancy Trimester, First;  Prospective Studies;  Registries;  Ultrasonography, Prenatal;  Uterine Artery",
    abstract = "Objective: The study aims to evaluate the predictive value of first trimester placental volume in pregnancies destined to develop fetal growth restriction (FGR) and preeclampsia (PE). Methods: Prospective observational study including placentas from 34 FGR, 12 PE, 15 GH (gestational hypertension) pregnancies, and 265 controls. Placental volume (PV) was obtained using VOCAL technique, and a z score was calculated (z-PV). The association of PV with other first trimester variables and maternal characteristics was assessed with Spearman's correlation. Results: PV increased exponentially with crown-rump length (CRL) and was unrelated to maternal factors (weight, age, parity, and smoking status) as well as first trimester uterine artery Doppler, free β-hCG, nuchal translucency, or fetal heart rate. However, PV was positively associated with maternal height, CRL, PAPP-A, and birth weight. z-PV was a strong predictor for FGR with abnormal fetal Dopplers (AUC = 0.9472, P < 0.001). z-PV provided moderate prediction of FGR with normal fetal Dopplers (AUC = 0.8396, P < 0.001), PE (AUC = 0.8312, P < 0.001), and GH (AUC = 0.7640, P < 0.001). The addition of maternal weight, PAPP-A, β-hCG, and uterine artery Doppler improved our models. Conclusion: At 11 to 14 weeks, PV is an independent predictor of pregnancy complications related to placental insufficiency, and the predictive ability is greater for FGR pregnancies with abnormal fetal Dopplers. © 2018 John Wiley & Sons, Ltd."
}