@article{3123067,
    title = "Endometrial CRH and implantation: from bench to bedside",
    author = "Makrigiannakis, A. and Vrekoussis, T. and Zoumakis, E. and Hatzidakis, V. and Vlachou, E. and Salakos, N. and Kalantaridou, S.N.",
    journal = "Vitamins and Hormones",
    year = "2018",
    volume = "17",
    number = "3",
    pages = "293-297",
    publisher = "Springer-Verlag",
    doi = "10.1007/s42000-018-0042-4",
    keywords = "corticotropin releasing factor;  corticotropin releasing factor, adenomyosis;  embryo transfer;  endometriosis;  endometrium;  endometrium carcinoma;  evidence based practice;  hormonal therapy;  hormone action;  human;  in vitro fertilization;  nonhuman;  pathophysiology;  preeclampsia;  pregnancy rate;  Review;  spontaneous abortion;  embryo transfer;  endometrium;  female;  in vitro fertilization;  metabolism;  nidation;  physiology;  uterus disease, Corticotropin-Releasing Hormone;  Embryo Implantation;  Embryo Transfer;  Endometrium;  Female;  Fertilization in Vitro;  Humans;  Uterine Diseases",
    abstract = "Endometrial corticotropin-releasing hormone (CRH) has been described as a mediator of decidualisation and as a contributor of maternal–fetal immunotolerance. Deregulation of the CRH expression pattern has been associated with unfavourable reproductive outcomes as well as chronic endometrium-derived inflammatory disorders, such as endometriosis and adenomyosis. The current review summarises the evidence produced regarding the role of CRH in endometrial physiology and pathophysiology and highlights recent clinical data regarding the role of CRH in improving clinical pregnancy rates in women with repeated implantation failures following in vitro fertilisation and embryo transfer. © 2018, Hellenic Endocrine Society."
}