@article{3124365,
    title = "Correlation of spleen metabolism assessed by 18F-FDG PET with serum interleukin-2 receptor levels and other biomarkers in patients with untreated sarcoidosis",
    author = "Kalkanis, A. and Kalkanis, D. and Drougas, D. and Vavougios, G.D. and Datseris, I. and Judson, M.A. and Georgiou, E.",
    journal = "Nuclear Medicine Communications",
    year = "2016",
    volume = "37",
    number = "3",
    pages = "273-277",
    publisher = "Lippincott Williams and Wilkins",
    issn = "0143-3636, 1473-5628",
    doi = "10.1097/MNM.0000000000000431",
    keywords = "biological marker;  C reactive protein;  calcium;  dipeptidyl carboxypeptidase;  fluorodeoxyglucose f 18;  interleukin 2 receptor;  biological marker;  fluorodeoxyglucose f 18;  interleukin 2 receptor, adult;  Article;  calcium urine level;  chemical parameters;  clinical article;  computer assisted emission tomography;  controlled study;  drug uptake;  female;  human;  male;  PET-CT scanner;  prospective study;  protein blood level;  sarcoidosis;  spleen;  spleen function;  spleen metabolism;  splenomegaly;  standard uptake value;  tissue metabolism;  whole body scintiscanning;  blood;  diagnostic imaging;  metabolism;  positron emission tomography;  sarcoidosis;  spleen;  transport at the cellular level, Adult;  Biological Transport;  Biomarkers;  Female;  Fluorodeoxyglucose F18;  Humans;  Male;  Positron-Emission Tomography;  Receptors, Interleukin-2;  Sarcoidosis;  Spleen",
    abstract = "Background The objective of our study was to assess the possible relationship between splenic F-18-fluorodeoxyglucose (18F-FDG) uptake and other established biochemical markers of sarcoidosis activity. Patients and methods Thirty treatment-naive sarcoidosis patients were prospectively enrolled in this study. They underwent biochemical laboratory tests, including serum interleukin-2 receptor (sIL-2R), serum C-reactive protein, serum angiotensin-I converting enzyme, and 24-h urine calcium levels, and a whole-body combined 18F-FDG PET/computed tomography (PET/CT) scan as a part of an ongoing study at our institute. These biomarkers were statistically compared in these patients. Results A statistically significant linear dependence was detected between sIL-2R and log-transformed spleen-average standard uptake value (SUV avg) (R 2 =0.488, P<0.0001) and log-transformed spleen-maximum standard uptake value (SUV max) (R 2 =0.490, P<0.0001). sIL-2R levels and splenic size correlated linearly (Pearson's r=0.373, P=0.042). Multivariate linear regression analysis revealed that this correlation remained significant after age and sex adjustment (β=0.001, SE=0.001, P=0.024). No statistically significant associations were detected between (a) any two serum biomarkers or (b) between spleen-SUV measurements and any serum biomarker other than sIL-2R. Conclusion Our analysis revealed an association between sIL-2R levels and spleen 18F-FDG uptake and size, whereas all other serum biomarkers were not significantly associated with each other or with PET 18F-FDG uptake. Our results suggest that splenic inflammation may be related to the systemic inflammatory response in sarcoidosis that may be associated with elevated sIL-2R levels. © 2016 Wolters Kluwer Health, Inc. All rights reserved."
}