@article{3124924,
    title = "Meta-analysis of the effect of stent design on 30-day outcome after carotid artery stenting",
    author = "Kouvelos, G.N. and Patelis, N. and Antoniou, G.A. and Lazaris, A. and Matsagkas, M.I.",
    journal = "Journal of Endovascular Therapy",
    year = "2015",
    volume = "22",
    number = "5",
    pages = "789-797",
    publisher = "Allen Press, Inc.",
    issn = "1526-6028, 1545-1550",
    doi = "10.1177/1526602815598753",
    keywords = "Article;  carotid artery stent;  carotid artery stenting;  cerebrovascular accident;  closed cell stent;  Embase;  equipment design;  human;  Medline;  meta analysis;  morbidity;  mortality;  open cell stent;  priority journal;  systematic review;  transient ischemic attack;  treatment outcome;  adverse effects;  aged;  angioplasty;  Carotid Artery Diseases;  chi square distribution;  complication;  devices;  female;  Ischemic Attack, Transient;  male;  middle aged;  odds ratio;  prosthesis design;  risk assessment;  risk factor;  stent;  Stroke;  time factor, Aged;  Angioplasty;  Carotid Artery Diseases;  Chi-Square Distribution;  Female;  Humans;  Ischemic Attack, Transient;  Male;  Middle Aged;  Odds Ratio;  Prosthesis Design;  Risk Assessment;  Risk Factors;  Stents;  Stroke;  Time Factors;  Treatment Outcome",
    abstract = "Purpose: To review the contemporary literature and analyze whether stent cell design plays a role in 30-day outcomes after carotid artery stenting (CAS). Methods: A systematic review of the literature was undertaken that identified 9 studies comparing the effect of different cell design on 30-day outcome in patients undergoing CAS. Random-effects models were applied to calculate pooled outcome data for mortality and cerebrovascular morbidity. Results are reported as the odds ratio (OR) and 95% confidence interval (CI). Results: The 9 studies included 8018 patients who underwent 8028 CAS procedures (4018 open-cell stents, 4010 closed-cell stents). Six studies were retrospective in design, one was a registry, and only two studies prospectively compared the effect of different cell designs. Nearly half of the patients (3452, 43.1%) were symptomatic, with no significant difference between the closed- and open-cell stent groups (p=0.93). During the first month after the procedure, there were no significant differences in mortality (OR 0.69, 95% CI 0.39 to 1.24, p=0.21), transient ischemic attacks (OR 0.95, 95% CI 0.69 to 1.30, p=0.74), or strokes (OR 1.17, 95% CI 0.83 to 1.66, p=0.37). Conclusion: This meta-analysis showed that 30-day cerebrovascular complications after CAS were not significantly different for the open-cell group in comparison to the closed-cell group. Future prospective clinical trials comparing different free cell areas and other stent design properties are still needed to further investigate whether stent design plays a significant role in the results of carotid stenting. © The Author(s) 2015."
}