@article{3125290,
    title = "Hypoxia-inducible factor-1α (HIF-1α) expression in placentae of women with iron deficiency anemia and β-thalassemia trait",
    author = "Michalitsi, V. and Dafopoulos, K. and Gourounti, K. and Messini, C. and Ioannou, M. and Christodoulaki, C. and Panagopoulos, P. and Messinis, I.",
    journal = "Journal of Maternal-Fetal and Neonatal Medicine",
    year = "2015",
    volume = "28",
    number = "4",
    pages = "470-474",
    publisher = "LIBRAPHARM/INFORMA HEALTHCARE",
    issn = "1476-7058, 1476-4954",
    doi = "10.3109/14767058.2014.921672",
    keywords = "ferritin;  hemoglobin;  hypoxia inducible factor 1alpha;  iron;  transferrin;  transferrin receptor;  HIF1A protein, human;  hypoxia inducible factor 1alpha, adult;  Apgar score;  Article;  beta thalassemia;  birth weight;  controlled study;  female;  gestational age;  hematocrit;  hematological parameters;  human;  human tissue;  immunohistochemistry;  immunoreactivity;  iron blood level;  iron deficiency anemia;  major clinical study;  mean corpuscular volume;  newborn hypoxia;  placenta;  placenta weight;  pregnancy outcome;  primipara;  priority journal;  protein expression;  tissue section;  trophoblast;  Western blotting;  Anemia, Iron-Deficiency;  beta-Thalassemia;  case control study;  complication;  metabolism;  pathology;  placenta;  pregnancy;  Pregnancy Complications, Hematologic;  young adult, Adult;  Anemia, Iron-Deficiency;  beta-Thalassemia;  Case-Control Studies;  Female;  Humans;  Hypoxia-Inducible Factor 1, alpha Subunit;  Immunohistochemistry;  Placenta;  Pregnancy;  Pregnancy Complications, Hematologic;  Pregnancy Outcome;  Young Adult",
    abstract = "Objective: To investigate hypoxia-inducible factor-1α (HIF-1α) expression in placentae of women with iron-deficiency anemia and β-thalassemia trait and to correlate the results with hematological parameters as well as with parameters associated with the outcome of pregnancy. Methods: About 126 women who delivered in the Larissa University Hospital were divided in three groups: iron-deficiency anemia (n=39), β-thalassemia trait carriers (n=53) and control group (n=34). HIF-1α expression was assessed with immunochemical assays and statistical analysis was performed with chi-squared test and ANOVA. Results: HIF-1α immunostaining was intense in the two groups of anemia. A statistically significant association was found between HIF-1α immunoreactivity and hematocrit (p<0.001), hemoglobin (p<0.001), MCV (p<0.001), transferrin (p<0.001) and its receptors (p=0.040), whereas no significant correlations were observed between HIF-1α, iron serum levels (p=0.256) and ferritin (p=0.232). We found no association between HIF-1α and birthweight (p=0.256), placental weight (p=0.870) and Apgar score at 1′ (p=0.210) and 5′ (p=0.400). Conclusions: HIF-1α expression is affected by anemia, although this factor has no important direct effect on the perinatal outcome. © 2014 Informa UK Ltd. All rights reserved: reproduction in whole or part not permitted."
}