@article{3126513,
    title = "Impact of statin therapy on all-cause mortality and ICD interventions in heart failure patients – A systematic review",
    author = "Bazoukis, G. and Papadatos, S.S. and Letsas, K.P. and Pagkalidou, E. and Korantzopoulos, P.",
    journal = "Acta Cardiologica Sinica",
    year = "2017",
    volume = "72",
    number = "5",
    pages = "547-552",
    publisher = "Taylor and Francis Ltd.",
    doi = "10.1080/00015385.2017.1310562",
    keywords = "statin (protein);  hydroxymethylglutaryl coenzyme A reductase inhibitor, bibliographic database;  cardiac sarcoidosis;  cardiomyopathy;  channelopathy;  congestive cardiomyopathy;  heart arrhythmia;  heart death;  heart failure;  heart ventricle tachycardia;  human;  ischemic cardiomyopathy;  mortality;  Review;  systematic review;  valvular heart disease;  heart failure;  implantable cardioverter defibrillator;  mortality;  sudden cardiac death;  survival analysis, Death, Sudden, Cardiac;  Defibrillators, Implantable;  Heart Failure;  Humans;  Hydroxymethylglutaryl-CoA Reductase Inhibitors;  Survival Analysis",
    abstract = "Objectives: Implantable cardioverter defibrillators (ICDs) have a unique role for the primary and secondary prevention of sudden cardiac death (SCD). The aim of our systematic review is to present the existing data about the impact of statins on all-cause mortality and ICD interventions in heart failure (HF) patients who had an ICD implanted either for primary or for secondary prevention of SCD. Methods and results: We searched PubMed database and the reference list of the relevant studies for retrieving studies evaluating the effect of statins on all-cause mortality and ICD interventions in HF patients. We finally included 17 relevant studies in our systematic review. Of them, nine studies included data about the impact of statins on all-cause mortality, eight studies about the impact of statins on appropriate ICD interventions and three studies about the impact of statins on inappropriate ICD interventions in HF patients. These data showed that statins seem to have a beneficial role in the reduction of all-cause mortality and ICD interventions in HF patients. Conclusions: Statins seem to have a beneficial role in the reduction of all-cause mortality and ICD interventions in HF patients. However, further research about pleiotropic effects of statins is needed as well randomized control trials to elucidate the exact role of statin therapy in ICD outcomes. © 2017 Belgian Society of Cardiology."
}