@article{3128334,
    title = "Cord blood chemerin and obestatin levels in large for gestational age infants",
    author = "Boutsikou, T. and Briana, D.D. and Boutsikou, M. and Kafalidis, G. and Stamati, L. and Baka, S. and Hassiakos, D. and Gourgiotis, D. and Malamitsi-Puchner, A.",
    journal = "Journal of Maternal-Fetal and Neonatal Medicine",
    year = "2013",
    volume = "26",
    number = "2",
    pages = "123-126",
    issn = "1476-7058, 1476-4954",
    doi = "10.3109/14767058.2012.728648",
    keywords = "chemerin;  insulin;  obestatin, adipose tissue;  article;  blood analysis;  body fat;  disease association;  disease marker;  human;  insulin blood level;  insulin resistance;  large for gestational age;  metabolic syndrome X;  priority journal;  protein blood level;  protein secretion;  umbilical cord blood, Adult;  Birth Weight;  Chemokines;  Female;  Fetal Blood;  Ghrelin;  Humans;  Infant, Newborn;  Insulin;  Male;  Pregnancy",
    abstract = "Objective: To investigate possible alterations in cord blood levels of adipokines, chemerin and obestatin (secreted by adipose tissue and associated with later development of insulin resistance/metabolic syndrome), as well as insulin, in large for gestational age (LGA) and appropriate for gestational age (AGA) pregnancies, granted that these groups differ in body fat mass and metabolic/endocrine mechanisms. Methods: Cord blood chemerin, obestatin, and insulin concentrations were prospectively measured in 40 LGA (9 born from diabetic and 31 from nondiabetic mothers) and 40 AGA singleton full-term infants. Results: Cord blood chemerin concentrations were significantly higher in LGA compared with AGA neonates (b = 38.91, SE 9.29, p < 0.001). In contrast, no significant differences in obestatin concentrations were observed between groups. Insulin levels were significantly elevated as customized centiles increased (b = 0.003, SE = 0.001, p = 0.032). Conclusions: Higher chemerin concentrations in LGA neonates possibly reflect the increased adipose tissue in this group. Lack of difference between the two groups in circulating levels of obestatin-possibly a sensitive marker of insulin resistance-might be due to development of metabolic disorders later in life. © 2013 Informa UK, Ltd."
}