@article{3128640,
    title = "Changes in hormonal profile and seminal parameters with use of aromatase inhibitors in management of infertile men with low testosterone to estradiol ratios",
    author = "Gregoriou, O. and Bakas, P. and Grigoriadis, C. and Creatsa, M. and Hassiakos, D. and Creatsas, G.",
    journal = "International Journal of Fertility and Sterility",
    year = "2012",
    volume = "98",
    number = "1",
    pages = "48-51",
    doi = "10.1016/j.fertnstert.2012.04.005",
    keywords = "anastrozole;  estradiol;  follitropin;  letrozole;  luteinizing hormone;  prolactin;  testosterone, adult;  article;  clinical article;  estrogen blood level;  follitropin blood level;  human;  luteinizing hormone blood level;  male;  male infertility;  priority journal;  prolactin blood level;  prospective study;  semen analysis;  spermatozoon count;  spermatozoon motility;  testosterone blood level;  testosterone to estradiol ratio;  urogenital system parameters, Adult;  Aromatase Inhibitors;  Estradiol;  Hormones;  Humans;  Infertility, Male;  Male;  Nitriles;  Organ Size;  Semen Analysis;  Testis;  Testosterone;  Triazoles",
    abstract = "Objective: To compare the effects of 2.5 mg letrozole with those of 1 mg anastrazole daily on the hormonal and semen profiles of a subset of infertile men with low T/E 2 ratios. Design: Prospective, nonrandomized study. Setting: Reproductive medicine clinic. Patient(s): The study group consisted of 29 infertile men with a low serum T/E 2 ratio (<10). Intervention(s): Patients were divided into two groups. Group A included 15 patients treated with 2.5 mg letrozole orally once daily for 6 months, and Group B consisted of 14 patients treated with 1 mg anastrazole orally every day for 6 months. Main Outcome Measure(s): Hormonal evaluation included measurement of serum FSH, LH, PRL, T, and E 2. In all sperm analyses pretreatment and posttreatment total motile sperm counts (ejaculate volume × concentration × motile fraction) were evaluated. Result(s): The use of aromatase inhibitors (either letrozole or anastrazole) in cases of infertile men with low T/E 2 ratios improved both hormonal and semen parameters. Conclusion(s): This study suggests that some men with severe oligospermia, low T levels, and normal gonadotropin concentration may have a treatable endocrinopathy. © 2012 American Society for Reproductive Medicine, Published by Elsevier Inc."
}