@article{3129874,
    title = "Prognostic significance of angiogenesis in relation to Ki-67, p-53, p-27, and bcl-2 expression in embryonal tumors",
    author = "Moschovi, M. and Koultouki, E. and Stefanaki, K. and Sfakianos, G. and Tourkantoni, N. and Prodromou, N. and Alexiou, G.A.",
    journal = "Pediatric Neurosurgery",
    year = "2011",
    volume = "47",
    number = "4",
    pages = "241-247",
    publisher = "S Karger AG",
    issn = "1016-2291, 1423-0305",
    doi = "10.1159/000335398",
    keywords = "carboplatin;  cisplatin;  cyclophosphamide;  etoposide;  Ki 67 antigen;  methotrexate;  protein bcl 2;  protein p27;  protein p53;  vincristine, adolescent;  angiogenesis;  article;  benign tumor;  blood vessel;  cancer chemotherapy;  child;  clinical article;  density;  embryonal tumor;  female;  human;  male;  medulloblastoma;  overall survival;  preschool child;  priority journal;  prognosis;  progression free survival;  protein expression;  retrospective study;  rhabdoid tumor;  school child;  teratoma",
    abstract = "Aim: We investigated the angiogenesis and density of newly formed blood vessels in embryonal tumors in relation to Ki-67, bcl-2, p-53 and p-27 expression. Methods: Forty-five children with embryonal tumors were enrolled in the study. Forty patients had a medulloblastoma (MB) and 5 patients had atypical teratoid/rhabdoid tumor (AT/RT). Results: In MB, the 5-year PFS and OS was 62.5 and 70%, respectively. Patients with Ki-67 index >50%, bcl-2 index >30% and higher density of new vessels were associated with worse survival. In the multivariate analysis, Ki-67 index was identified as a factor with independent prognostic power. In AT/RTs, high density of new vessels (>25 HRF) was observed in 3 patients and Ki-67 index over 25% was found in 4 patients. Conclusion: Increased Ki-67, bcl-2 and density of new vessels are of prognostic value for the disease outcome in MB. Copyright © 2012 S. Karger AG, Basel."
}