@article{3134779,
    title = "The management of HCV infected pregnant women and their children European paediatric HCV network",
    author = "Pembrey, L. and Newell, M.-L. and Tovo, P.-A. and Amoroso, A. and Bevilaqua, E. and Asensi-Botet, F. and Pereda, A. and Balossini, V. and Bona, G. and Zaffaroni, M. and Bandelloni, A. and Coscia, A. and Fabris, C. and Aime, S. and Belloni, C. and Bossi, G. and Salati, B. and Boucher, C. and Buffolano, W. and Butler, K. and Roura, L.C. and Sanges, J.M.B. and Cigna, P. and Ciria, L.M. and Ginard, C.S. and Teruel, G.C. and Fortuny, C. and Coll, O. and Corrias, A. and Ledda, R. and Floris, S. and De Maria, A. and Echeverria, J. and Cilla, G. and Faldella, G. and Lanari, M. and Tridapalli, E. and Venturi, V. and Fischler, B. and Bohlin, A.-B. and Lindgren, S. and Lindh, G. and Giacomet, V. and Merlo, M. and Figini, C. and Erba, P. and Viganò, A. and Hannam, S. and Mieli-Vergani, G. and Hatzakis, A. and Inchley, C. and Fjaerli, H.O. and Maccabruni, A. and Marcellini, M. and Sartorelli, M.R. and Fontelos, P.M. and Mazza, A. and Mok, J.Y.Q. and Mûr, A. and Viñolas, M. and Paternoster, D.M. and Grella, P. and Polywka, S. and Quinti, I. and Casadei, A.M. and Rojahn, A. and Berg, A. and Rosso, R. and Ferrando, S. and Bassetti, D. and Contreras, J.R. and Manzanares, A. and Extremera, A.R. and Salvini, F. and Zuccotti, G.V. and Schmitz, T. and Grosch-Wörner, I. and Sperling, C.F. and Piening, T. and Vegnente, A. and Iorio, R. and Versace, A. and Lazier, L. and Palomba, E. and Gabiano, C. and Balbo, L. and Zanetti, A. and Tanzi, E.",
    journal = "WORLD JOURNAL OF HEPATOLOGY",
    year = "2005",
    volume = "43",
    number = "3",
    pages = "515-525",
    publisher = "Elsevier B.V.",
    doi = "10.1016/j.jhep.2005.06.002",
    keywords = "maternal antibody;  peginterferon;  recombinant alpha interferon;  recombinant alpha2b interferon;  ribavirin, anorexia;  body weight disorder;  breast feeding;  cesarean section;  child;  childhood disease;  clinical protocol;  diagnostic accuracy;  diagnostic test;  evidence based medicine;  fatigue;  female;  flu like syndrome;  follow up;  gestation period;  hepatitis C;  Hepatitis C virus;  human;  Human immunodeficiency virus infection;  infection risk;  intrauterine infection;  practice guideline;  pregnancy;  prenatal screening;  priority journal;  prospective study;  reliability;  review;  superinfection;  vertical transmission;  virus infectivity;  virus transmission;  weight reduction",
    abstract = "Background/Aims: As evidence accumulates relating to mother-to-child (vertical) transmission of hepatitis C virus (HCV), it is timely to draw up guidelines for the clinical management of HCV infected pregnant women and their children. Methods: A review of evidence from the European Paediatric HCV Network (EPHN) prospective study of HCV infected women and their children and other published studies. Meeting of EPHN clinical experts to reach a consensus on recommendations for management. Each recommendation was graded according to the level of evidence. Results/conclusions: Although several risk factors for mother-to-child transmission have been identified, none are modifiable and there are currently no interventions available to prevent vertical transmission of HCV. Data on timing of loss of maternal antibodies and reliability of diagnostic tests inform the optimum follow-up schedule for confirmation or exclusion of infection in children born to HCV infected women. Based on the current evidence, routine antenatal screening for HCV should not be introduced and neither elective caesarean section nor avoidance of breastfeeding should be recommended to HCV infected women to prevent mother-to-child transmission of HCV. HCV/HIV co-infected women should follow existing HIV guidelines. © 2005 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved."
}