@article{3136544,
    title = "Synergia of a heparinoid and promethazine hydrochloride against liver cell necrosis",
    author = "Bartsokas, St.K. and Papacharalampous, N.X. and Papadimitriou, D.G. and Katapoti, Z.",
    journal = "Research in Experimental Medicine",
    year = "1974",
    volume = "162",
    number = "3",
    pages = "235-241",
    publisher = "Springer-Verlag",
    issn = "0300-9130, 1433-8580",
    doi = "10.1007/BF01851245",
    keywords = "antihistaminic agent;  eosin;  hematoxylin;  heparinoid;  pentosan polysulfate;  promethazine;  thioacetamide, dose liver function relation;  drug administration;  drug potentiation;  drug toxicity;  intoxication;  liver;  liver injury;  liver necrosis;  rat;  theoretical study;  therapy, Animal;  Drug Synergism;  Drug Therapy, Combination;  Female;  Heparinoids;  Liver Cirrhosis, Experimental;  Male;  Promethazine",
    abstract = "The effects of combined treatment with a heparinoid-sodium pentosan polysulfate - and an antihistamine-promethazine hydrochloride - against thioacetamide-induced rat liver injury were studied. Treatment by promethazine hydrochloride at 0 and 6 hrs by 2.5 and 1.25 mg per 100 g body weight or by 1.5 mg pentosan polysulfate did not afford a real protection against liver injury. The combined, however, of these two incompletely acting schedules treatment inhibited substantially the development of liver cellnecrosis up to 96 hrs. A synergic action of the above protective agents could be supposed. © 1974 Springer-Verlag."
}