@article{3138203,
    title = "Enlargement of the hypofluorescent post photodynamic therapy treatment
spot after a combination of photodynamic therapy with an intravitreal
injection of bevacizumab for retinal angiomatous proliferation",
    author = "Rouvas, Alexandros A. and Papakostas, Thanos D. and Ladas, Ioannis D. and and Vergados, Ioannis",
    journal = "Graefe's Archive for Clinical and Experimental Ophthalmology",
    year = "2008",
    volume = "246",
    number = "2",
    pages = "315-318",
    publisher = "Springer-Verlag",
    issn = "0721-832X, 1435-702X",
    doi = "10.1007/s00417-007-0669-3",
    keywords = "retinal angiomatous proliferation; age-related macular degeneration;
photodynamic therapy; bevacizumab; hypofluorescence",
    abstract = "Background To report a case of enlargement of the post photodynamic
therapy treatment (PDT) spot in a patient with retinal angiomatous
proliferation (RAP) that was treated with PDT combined with an
intravitreal injection of bevacizumab.
Methods 74-year-old woman with RAP due to age-related macular
degeneration was treated with one verteporfin PDT session, sequenced by
a single intravitreal injection of bevacizumab (1.25 mg) after 30
minutes.
Results The patient’s visual acuity (VA) at baseline was 20/200 and is
now at the 10-month follow-up visit 20/400, while the RAP has
disappeared according to the indocyanine angiography (ICG) findings. The
post PDT hypofluorescent treatment spot has enlarged from 1,450 mu m at
the day of the treatment, to 5,360 mu m at the 6-week visit. The patient
is now at the 10-month follow-up visit and the hypofluorescence is still
persisting.
Conclusions The simultaneous combination of PDT with bevacizumab in
patients with RAP may enhance the photochemical stress in normal choroid
with prolonged and magnified hypofluorescence in ICG, due to ischemia in
normal choriocapillaries."
}