@article{3138912,
    title = "DNA variants, plasma levels and variability of C-reactive protein in
myocardial infarction survivors: results from the AIRGENE study",
    author = "Kolz, Melanie and Koenig, Wolfgang and Mueller, Martina and Andreani, and Mariarita and Greven, Sonja and Illig, Thomas and Khuseyinova, Natalie and and Panagiotakos, Demosthenes and Pershagen, Goeran and Salomaa, Veikko and and Sunyer, Jordi and Peters, Annette and AIRGENE Study Grp",
    journal = "EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY",
    year = "2008",
    volume = "29",
    number = "10",
    pages = "1250-1258",
    publisher = "Oxford University Press",
    doi = "10.1093/eurheartj/ehm442",
    keywords = "epidemiology; inflammation; genetics; C-reactive protein; myocardial
infarction",
    abstract = "Aims C-reactive protein represents the classical acute-phase protein
produced in the liver in response to inflammatory stimuli. This study
evaluated the association of gene polymorphisms with differences in
C-reactive protein concentrations and assessed its intra-individual
variability as a marker of individual response.
Methods and results One thousand and three myocardial infarction (MI)
survivors were recruited in six European cities, and C-reactive protein
concentrations were measured repeatedly during a 6-month period. We
investigated 114 polymorphisms in 13 genes, all involved in the innate
inflammatory pathway. We found two polymorphisms within the C-reactive
protein (CRP) gene rs1800947 and rs1205, of which the minor alleles were
strongly associated with lower levels of C-reactive protein (P <
10(-6)). A haplotype, identified by those two polymorphisms, was
associated with the lowest C-reactive protein concentrations (P <
10(-6)). Additionally, the minor alleles of several variants were
significantly associated with greater individual variability of
C-reactive protein concentrations (P < 10(-3)).
Conclusion The present study investigated the association of
polymorphisms with inter- and intra-individual variability of C-reactive
protein levels. Two minor alleles of C-reactive protein variants were
associated with lower C-reactive protein concentrations. Regarding
intra-individual variability, we observed associations with the minor
alleles of several variants in selected candidate genes, including the
CRP gene itself."
}