@article{3139984,
    title = "Correlation of Modification of Heart Rate Recovery with Adaptation to
Myocardial Ischemia in a Model of Sequential Exercise Testings",
    author = "Michaelides, Andreas P. and Fourlas, Christos A. and Andrikopoulos, and George K. and Antoniades, Charalambos and Soulis, Dimitrios and and Chatzistamatiou, Evangelos and Stefanadis, Christodoulos I.",
    journal = "Annals of Noninvasive Electrocardiology",
    year = "2008",
    volume = "13",
    number = "4",
    pages = "364-370",
    publisher = "Blackwell Publishing Inc.",
    issn = "1082-720X, 1542-474X",
    doi = "10.1111/j.1542-474X.2008.00247.x",
    keywords = "coronary artery disease; exercise testing; heart rate recovery;
myocardial ischemic preconditioning",
    abstract = "Background: Heart rate recovery (HRR) has been identified as a reliable
predictor of cardiac mortality, correlated with autonomic tone. In a
model of sequential exercise testings, we investigated the
reproducibility of HRR and the association between HRR modification and
myocardial adaptation to ischemia.
Methods: We studied 128 patients (mean age 62 +/- 9 years, 83% males)
with angiographically documented coronary artery disease (CAD) and a
first positive exercise testing, who agreed to undergo a second exercise
testing after 24 hours.
Results: HRR was increased from 25 +/- 10 beats/min at the first
exercise testing to 30 +/- 13 beats/min at the second exercise testing
(P < 0.001). Thereafter, participants were divided into two groups:
Group I comprised 88 patients who presented augmentation of the HRR in
the first compared to the second exercise testing, while group II
comprised 40 patients who presented unchanged or reduced HRR. The
rate-pressure product (RPP) at 1 mm ST-segment depression (ischemic
threshold) at the second compared to the first exercise testing were
significantly improved in group I patients (2345 +/- 3429 mmHg/min),
while it was worsened in group II patients (-630 +/- 2510 mmHg/min) (P <
0.001).
Conclusions: In a model of sequential exercise testings, myocardial
adaptation to exercise-induced ischemia was associated with favorable
modification of HRR."
}