@article{3140588,
    title = "Differences in presentation characteristics of renal cell carcinoma in
the last 25 years: a single center experience",
    author = "Mitropoulos, Dionisios and Petrolekas, Andreas and Anastasiou, Ioannis and and Adamakis, Ioannis and Kyroudi-Voulgari, Aspasia and Serafetinides, and Efraim and Zervas, Anastasios",
    journal = "Journal of Cancer Research and Clinical Oncology",
    year = "2008",
    volume = "134",
    number = "12",
    pages = "1297-1301",
    publisher = "Springer-Verlag",
    issn = "0171-5216, 1432-1335",
    doi = "10.1007/s00432-008-0420-4",
    keywords = "Renal cell carcinoma (RCC); Diagnosis; Detection; Histology; Staging",
    abstract = "Purpose The aim of this study was to examine trends in
clinicopathological characteristics of renal cell carcinoma (RCC) cases
at presentation in a single institution over a 25-years period.
Patients and methods The medical files of 505 patients with
histologically confirmed primary RCC from 1981 to 2006 were
retrospectively reviewed. Host and tumor characteristics at presentation
were compared following stratification by hospitalization period
(1981-1990, 1991-2000, and 2001-2006).
Results Age at presentation did not change significantly over time. The
incidentally diagnosed cases increased significantly by time (10.2,
40.5, 62.7%), in proportion to small (< 4 cm) tumors (8.6, 17.3,
30.6%), while tumor diameter decreased significantly (8.5 +/- 3.8, 7.4
+/- 3.5, 5.8 +/- 2.9). The rate of organ-confined tumors increased
significantly (42.1, 63.6, 68.9%), followed by a less pronounced
decrease of metastatic cases (12.3, 8.9, 6.8%).
Conclusions The evolution of tumor characteristics at presentation in a
single institution is apparent within the last 25 years. Major changes
were noticed within organ-confined and small tumors and call for
familiarization of urologists with nephron-sparing techniques and novel
ablation technologies."
}